Curt D Sigmund
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Explore the profile of Curt D Sigmund including associated specialties, affiliations and a list of published articles.
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229
Citations
6826
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Recent Articles
1.
Fekete E, Gomez J, Ghobrial M, Kaminski K, Muskus P, Boychuk C, et al.
Hypertension
. 2024 Dec;
82(2):282-292.
PMID: 39618396
Background: The importance of the brain renin-angiotensin system in cardiovascular function is well accepted. However, not knowing the precise source of renin in the brain has been a limitation toward...
2.
Ziegler A, Lawton S, Fekete E, Brozoski D, Wagner V, Grobe C, et al.
Am J Physiol Regul Integr Comp Physiol
. 2024 Nov;
328(1):R109-R120.
PMID: 39548798
Preterm birth increases the risk of cardiometabolic disease in adulthood. Infants born during the second trimester of pregnancy, a critical period of hypothalamic development, are at risk of sodium (Na)...
3.
Lawton S, Wagner V, Nakagawa P, Segar J, Sigmund C, Morselli L, et al.
Hypertension
. 2024 Sep;
81(11):2209-2217.
PMID: 39315447
The American Heart Association has identified obesity as a primary impediment to ongoing improvements in cardiovascular diseases, including hypertension. Although drugs, exercise, diets, and surgeries can each cause weight loss,...
4.
Medrano S, Yamaguchi M, Almeida L, Smith J, Yamaguchi H, Sigmund C, et al.
Am J Physiol Renal Physiol
. 2024 Jul;
327(3):F489-F503.
PMID: 38991008
Fate mapping and genetic manipulation of renin cells have relied on either noninducible lines that can introduce the developmental effects of gene deletion or bacterial artificial chromosome transgene-based inducible models...
5.
Mathieu N, Tan E, Reho J, Brozoski D, Muskus P, Lu K, et al.
Hypertension
. 2024 Apr;
81(6):1332-1344.
PMID: 38629290
Background: ANG (angiotensin II) elicits dipsogenic and pressor responses via activation of the canonical Gαq (G-protein component of the ATR [angiotensin type 1 receptor])-mediated ATR in the subfornical organ. Recently,...
6.
Cavallero S, Roustaei M, Satta S, Cho J, Phan H, In Baek K, et al.
Sci Adv
. 2024 Feb;
10(7):eadj7481.
PMID: 38354249
Exercise promotes pulsatile shear stress in the arterial circulation and ameliorates cardiometabolic diseases. However, exercise-mediated metabolic transducers for vascular protection remain under-investigated. Untargeted metabolomic analysis demonstrated that wild-type mice undergoing...
7.
Reho J, Muskus P, Bennett D, Grobe C, Burnett C, Nakagawa P, et al.
Am J Physiol Regul Integr Comp Physiol
. 2024 Jan;
326(3):R242-R253.
PMID: 38284128
The estrous cycle is known to modify food, fluid, and electrolyte intake behaviors and energy homeostasis in various species, in part through fluctuations in estrogen levels. Simultaneously, commonly commercially available...
8.
Sigmund C
Function (Oxf)
. 2024 Jan;
5(1):zqad071.
PMID: 38196837
Human genetic and clinical trial data suggest that peroxisome proliferator activated receptor γ (PPARγ), a nuclear receptor transcription factor plays an important role in the regulation of arterial blood pressure....
9.
Ritter M, Wagner V, Balapattabi K, Opichka M, Lu K, Wackman K, et al.
Physiol Genomics
. 2023 Dec;
56(3):265-275.
PMID: 38145289
Agouti-related peptide (AgRP/) within the hypothalamic arcuate nucleus (ARC) contributes to the control of energy balance, and dysregulated may contribute to metabolic adaptation during prolonged obesity. In mice, three isoforms...
10.
Opichka M, Livergood M, Balapattabi K, Ritter M, Brozoski D, Wackman K, et al.
Sci Adv
. 2023 Dec;
9(48):eadg8118.
PMID: 38039359
Syncytiotrophoblast stress is theorized to drive development of preeclampsia, but its molecular causes and consequences remain largely undefined. Multiple hormones implicated in preeclampsia signal via the Gαq cascade, leading to...