Larry J Friedman
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Explore the profile of Larry J Friedman including associated specialties, affiliations and a list of published articles.
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37
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1136
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Recent Articles
1.
Jeon J, Friedman L, Zhou D, Seo H, Adeleke O, Graham B, et al.
Nat Struct Mol Biol
. 2025 Jan;
PMID: 39809941
Transcription activators are said to stimulate gene expression by 'recruiting' coactivators, yet this vague term fits multiple kinetic models. To directly analyze the dynamics of activator-coactivator interactions, single-molecule microscopy was...
2.
Zhou D, Jeon J, Farheen N, Friedman L, Kondev J, Buratowski S, et al.
bioRxiv
. 2024 Dec;
PMID: 39713438
Transcription activators trigger transcript production by RNA Polymerase II (RNApII) via the Mediator coactivator complex. Here the dynamics of activator, Mediator, and RNApII binding at promoter DNA were analyzed using...
3.
Jeon J, Friedman L, Seo H, Adeleke A, Graham B, Patteson E, et al.
bioRxiv
. 2023 Aug;
PMID: 37609355
Transcription activators are said to stimulate gene expression by "recruiting" coactivators to promoters, yet this term fits several different kinetic models. To directly analyze dynamics of activator-coactivator interactions, single-molecule microscopy...
4.
Zhang A, Friedman L, Gelles J, Bell S
Proc Natl Acad Sci U S A
. 2023 Jul;
120(30):e2305556120.
PMID: 37463200
During origin licensing, the eukaryotic replicative helicase Mcm2-7 forms head-to-head double hexamers to prime origins for bidirectional replication. Recent single-molecule and structural studies revealed that one molecule of the helicase...
5.
Tenenbaum D, Inlow K, Friedman L, Cai A, Gelles J, Kondev J
Proc Natl Acad Sci U S A
. 2023 Jul;
120(30):e2301402120.
PMID: 37459525
DNA transcription initiates after an RNA polymerase (RNAP) molecule binds to the promoter of a gene. In bacteria, the canonical picture is that RNAP comes from the cytoplasmic pool of...
6.
Amasino A, Gupta S, Friedman L, Gelles J, Bell S
Proc Natl Acad Sci U S A
. 2023 Jul;
120(29):e2221484120.
PMID: 37428921
Eukaryotic DNA replication must occur exactly once per cell cycle to maintain cell ploidy. This outcome is ensured by temporally separating replicative helicase loading (G1 phase) and activation (S phase)....
7.
Inlow K, Tenenbaum D, Friedman L, Kondev J, Gelles J
Proc Natl Acad Sci U S A
. 2023 Jul;
120(28):e2303849120.
PMID: 37406096
Free-living bacteria have regulatory systems that can quickly reprogram gene transcription in response to changes in the cellular environment. The RapA ATPase, a prokaryotic homolog of the eukaryotic Swi2/Snf2 chromatin...
8.
Zhang A, Friedman L, Gelles J, Bell S
bioRxiv
. 2023 Jul;
PMID: 37398123
Significance Statement: Bidirectional DNA replication, in which two replication forks travel in opposite directions from each origin of replication, is required for complete genome duplication. To prepare for this event,...
9.
Inlow K, Tenenbaum D, Friedman L, Kondev J, Gelles J
bioRxiv
. 2023 Mar;
PMID: 36993374
Significance: RNA synthesis is an essential conduit of genetic information in all organisms. After transcribing an RNA, the bacterial RNA polymerase (RNAP) must be reused to make subsequent RNAs, but...
10.
Amasino A, Gupta S, Friedman L, Gelles J, Bell S
bioRxiv
. 2023 Jan;
PMID: 36711604
Significance Statement: Each time a eukaryotic cell divides (by mitosis) it must duplicate its chromosomal DNA exactly once to ensure that one full copy is passed to each resulting cell....