Larry H Matherly
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Explore the profile of Larry H Matherly including associated specialties, affiliations and a list of published articles.
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125
Citations
2785
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Recent Articles
11.
Dekhne A, Shah K, Ducker G, Katinas J, Wong-Roushar J, Nayeen M, et al.
Mol Cancer Ther
. 2023 Jan;
22(2):287.
PMID: 36602953
No abstract available.
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Matherly L, Schneider M, Gangjee A, Hou Z
Expert Opin Drug Metab Toxicol
. 2022 Oct;
18(10):695-706.
PMID: 36239195
Introduction: The proton-coupled folate transporter (PCFT; SLC46A1) was discovered in 2006 as the principal mechanism by which folates are absorbed in the intestine and the causal basis for hereditary folate...
14.
Wallace-Povirk A, Rubinsak L, Malysa A, Dzinic S, Ravindra M, Schneider M, et al.
Sci Rep
. 2022 Jul;
12(1):11346.
PMID: 35790779
Novel therapies are urgently needed for epithelial ovarian cancer (EOC), the most lethal gynecologic malignancy. In addition, therapies that target unique vulnerabilities in the tumor microenvironment (TME) of EOC have...
15.
Burton J, Carruthers N, Hou Z, Matherly L, Stemmer P
Proteomes
. 2022 Jun;
10(2).
PMID: 35645376
Localization of organelle proteins by isotope tagging (LOPIT) maps are a coordinate-directed representation of proteome data that can aid in biological interpretation. Analysis of organellar association for proteins as displayed...
16.
Hou Z, Gangjee A, Matherly L
FASEB J
. 2022 Jan;
36(2):e22164.
PMID: 35061292
The human proton-coupled folate transporter (PCFT; SLC46A1) or hPCFT was identified in 2006 as the principal folate transporter involved in the intestinal absorption of dietary folates. A rare autosomal recessive...
17.
Wallace-Povirk A, Hou Z, Nayeen M, Gangjee A, Matherly L
Cancers (Basel)
. 2022 Jan;
14(1).
PMID: 35008360
New therapies are urgently needed for epithelial ovarian cancer (EOC), the most lethal gynecologic malignancy. To identify new approaches for targeting EOC, metabolic vulnerabilities must be discovered and strategies for...
18.
Heravi G, Yazdanpanah O, Podgorski I, Matherly L, Liu W
Cancer Metastasis Rev
. 2021 Nov;
41(1):17-31.
PMID: 34741716
Metabolic reprogramming is recognized as a hallmark of cancer. Lipids are the essential biomolecules required for membrane biosynthesis, energy storage, and cell signaling. Altered lipid metabolism allows tumor cells to...
19.
Wallace-Povirk A, Tong N, Wong-Roushar J, OConnor C, Zhou X, Hou Z, et al.
Bioorg Med Chem
. 2021 Mar;
37:116093.
PMID: 33773393
We discovered 6-substituted thieno[2,3-d]pyrimidine compounds (3-9) with 3-4 bridge carbons and side-chain thiophene or furan rings for dual targeting one-carbon (C1) metabolism in folate receptor- (FR) expressing cancers. Synthesis involved...
20.
OConnor C, Wallace-Povirk A, Ning C, Fruhauf J, Tong N, Gangjee A, et al.
Sci Rep
. 2021 Mar;
11(1):6389.
PMID: 33737637
There are three major folate uptake systems in human tissues and tumors, including the reduced folate carrier (RFC), folate receptors (FRs) and proton-coupled folate transporter (PCFT). We studied the functional...