Lance M Hellman
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Explore the profile of Lance M Hellman including associated specialties, affiliations and a list of published articles.
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33
Citations
1173
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Recent Articles
1.
Singh N, Alonso J, Devlin J, Keller G, Gray G, Chiranjivi A, et al.
Nat Commun
. 2022 Nov;
13(1):7189.
PMID: 36424374
MHC restriction, which describes the binding of TCRs from CD4 T cells to class II MHC proteins and TCRs from CD8 T cells to class I MHC proteins, is a...
2.
Liu C, Liu H, Dasgupta M, Hellman L, Zhang X, Qu K, et al.
Sci Rep
. 2022 Jul;
12(1):12068.
PMID: 35840635
Monoclonal antibodies are at the vanguard of the most promising cancer treatments. Whereas traditional therapeutic antibodies have been limited to extracellular antigens, T cell receptor mimic (TCRm) antibodies can target...
3.
Ma J, Ayres C, Hellman L, Devlin J, Baker B
J Biol Chem
. 2021 Apr;
296:100686.
PMID: 33891944
Using a variety of activating and inhibitory receptors, natural killer (NK) cells protect against disease by eliminating cells that have downregulated class I major histocompatibility complex (MHC) proteins, such as...
4.
Smith A, Alonso J, Ayres C, Singh N, Hellman L, Baker B
Proc Natl Acad Sci U S A
. 2021 Jan;
118(4).
PMID: 33468649
Presentation of peptides by class I MHC proteins underlies T cell immune responses to pathogens and cancer. The association between peptide binding affinity and immunogenicity has led to the engineering...
5.
Singh N, Alonso J, Harris D, Anderson S, Ma J, Hellman L, et al.
Biochemistry
. 2020 Oct;
59(43):4163-4175.
PMID: 33074657
T cell receptors (TCRs) orchestrate cellular immunity by recognizing peptides presented by a range of major histocompatibility complex (MHC) proteins. Naturally occurring TCRs bind the composite peptide/MHC surface, recognizing peptides...
6.
Ayres C, Abualrous E, Bailey A, Abraham C, Hellman L, Corcelli S, et al.
Front Immunol
. 2019 May;
10:966.
PMID: 31130956
T cell receptor (TCR) recognition of antigenic peptides bound and presented by class I major histocompatibility complex (MHC) proteins underlies the cytotoxic immune response to diseased cells. Crystallographic structures of...
7.
Hellman L, Foley K, Singh N, Alonso J, Riley T, Devlin J, et al.
Mol Ther
. 2019 Jan;
27(2):300-313.
PMID: 30617019
T cell receptors (TCRs) have emerged as a new class of immunological therapeutics. However, though antigen specificity is a hallmark of adaptive immunity, TCRs themselves do not possess the high...
8.
Riley T, Hellman L, Gee M, Mendoza J, Alonso J, Foley K, et al.
Nat Chem Biol
. 2018 Sep;
14(10):934-942.
PMID: 30224695
T cell receptor cross-reactivity allows a fixed T cell repertoire to respond to a much larger universe of potential antigens. Recent work has emphasized the importance of peptide structural and...
9.
Spear T, Wang Y, Smith Jr T, Simms P, Garrett-Mayer E, Hellman L, et al.
Mol Ther
. 2018 Mar;
26(4):996-1007.
PMID: 29503203
The use of T cell receptor (TCR) gene-modified T cells in adoptive cell transfer has had promising clinical success, but often, simple preclinical evaluation does not necessarily accurately predict treatment...
10.
Moore T, Wagner C, Scurti G, Hutchens K, Godellas C, Clark A, et al.
Cancer Immunol Immunother
. 2017 Dec;
67(2):327.
PMID: 29264697
The authors would like to make the following corrections to the published article.