Lance C Kam
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Explore the profile of Lance C Kam including associated specialties, affiliations and a list of published articles.
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46
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1704
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Recent Articles
1.
Schultheiss P, Pulkundwar A, Li W, Kam L
Cells
. 2025 Feb;
14(3).
PMID: 39936994
A central step in T-cell immunotherapy is the expansion of a starting population into therapeutically potent numbers of these "living drugs". This process can be enhanced by replacing the mechanically...
2.
Wang X, Fernandes S, Brown J, Kam L
BioMedInformatics
. 2024 Nov;
4(2):1144-1154.
PMID: 39525274
Immune cell function varies tremendously between individuals, posing a major challenge to emerging cellular immunotherapies. This report pursues the use of cell morphology as an indicator of high-level T cell...
3.
Winer B, Settle A, Yakimov A, Jeronimo C, Lazarov T, Tipping M, et al.
Sci Immunol
. 2024 Jun;
9(96):eadl2388.
PMID: 38848343
Professional phagocytes like neutrophils and macrophages tightly control what they consume, how much they consume, and when they move after cargo uptake. We show that plasma membrane abundance is a...
4.
Shi L, Lim J, Kam L
J Biomed Mater Res A
. 2024 Mar;
112(7):1138-1148.
PMID: 38450935
Induced Tregs (iTregs) have great promise in adoptive immunotherapy for treatment of autoimmune diseases. This report investigates the impacts of substrate stiffness on human Treg induction, providing a powerful yet...
5.
Wang M, Hu Y, Sanchez E, Xie X, Roy N, de Jesus M, et al.
Nat Commun
. 2023 Dec;
14(1):8401.
PMID: 38110360
No abstract available.
6.
Yang S, Palmquist K, Nathan L, Pfeifer C, Schultheiss P, Sharma A, et al.
Science
. 2023 Nov;
382(6673):eadg5579.
PMID: 37995219
During vertebrate organogenesis, increases in morphological complexity are tightly coupled to morphogen expression. In this work, we studied how morphogens influence self-organizing processes at the collective or "supra"-cellular scale in...
7.
Winer B, Settle A, Yakimov A, Jeronimo C, Lazarov T, Tipping M, et al.
bioRxiv
. 2023 Sep;
PMID: 37745515
Professional phagocytes like neutrophils and macrophages tightly control what they eat, how much they eat, and when they move after eating. We show that plasma membrane abundance is a key...
8.
Shi L, Lim J, Kam L
Biomaterials
. 2022 Dec;
292:121928.
PMID: 36455488
Regulatory T cells (Tregs) provide an essential tolerance mechanism to suppress the immune response. Induced Tregs hold the potential to treat autoimmune diseases in adoptive therapy and can be produced...
9.
Wang M, Hu Y, Sanchez E, Xie X, Roy N, de Jesus M, et al.
Nat Commun
. 2022 Jun;
13(1):3222.
PMID: 35680882
Cytotoxic lymphocytes fight pathogens and cancer by forming immune synapses with infected or transformed target cells and then secreting cytotoxic perforin and granzyme into the synaptic space, with potent and...
10.
Sachar C, Kam L
Front Immunol
. 2021 Sep;
12:704693.
PMID: 34566962
The ability of cells to recognize and respond to the mechanical properties of their environment is of increasing importance in T cell physiology. However, initial studies in this direction focused...