Chirag Sachar
Overview
Explore the profile of Chirag Sachar including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
81
Followers
0
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Recent Articles
1.
Wang K, Coutifaris P, Brocks D, Wang G, Azar T, Solis S, et al.
Cancer Cell
. 2024 Aug;
42(9):1582-1597.e10.
PMID: 39214097
Combination checkpoint blockade with anti-PD-1 and anti-CTLA-4 antibodies has shown promising efficacy in melanoma. However, the underlying mechanism in humans remains unclear. Here, we perform paired single-cell RNA and T ...
2.
Heczey A, Xu X, Courtney A, Tian G, Barragan G, Guo L, et al.
Nat Med
. 2024 Jan;
30(4):1210.
PMID: 38195754
No abstract available.
3.
Wang M, Hu Y, Sanchez E, Xie X, Roy N, de Jesus M, et al.
Nat Commun
. 2023 Dec;
14(1):8401.
PMID: 38110360
No abstract available.
4.
Heczey A, Xu X, Courtney A, Tian G, Barragan G, Guo L, et al.
Nat Med
. 2023 May;
29(6):1379-1388.
PMID: 37188782
Vα24-invariant natural killer T cells (NKTs) have anti-tumor properties that can be enhanced by chimeric antigen receptors (CARs). Here we report updated interim results from the first-in-human phase 1 evaluation...
5.
Wang M, Hu Y, Sanchez E, Xie X, Roy N, de Jesus M, et al.
Nat Commun
. 2022 Jun;
13(1):3222.
PMID: 35680882
Cytotoxic lymphocytes fight pathogens and cancer by forming immune synapses with infected or transformed target cells and then secreting cytotoxic perforin and granzyme into the synaptic space, with potent and...
6.
Sachar C, Kam L
Front Immunol
. 2021 Sep;
12:704693.
PMID: 34566962
The ability of cells to recognize and respond to the mechanical properties of their environment is of increasing importance in T cell physiology. However, initial studies in this direction focused...
7.
Mayya V, Judokusumo E, Abu-Shah E, Neiswanger W, Sachar C, Depoil D, et al.
J Immunol
. 2019 Jun;
203(3):601-606.
PMID: 31201237
Memory T cells are endowed with multiple functional features that enable them to be more protective than naive T cells against infectious threats. It is not known if memory cells...