Lakshmi Thirumangalakudi
Overview
Explore the profile of Lakshmi Thirumangalakudi including associated specialties, affiliations and a list of published articles.
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13
Citations
655
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Recent Articles
1.
Bhat N, Thirumangalakudi L
J Alzheimers Dis
. 2013 May;
36(4):781-9.
PMID: 23703152
Previous studies demonstrated that a high fat/high cholesterol (HFC) diet results in a loss of working memory in mice correlated with neuroinflammatory changes and increased AβPP processing (Thirumangalakudi et al....
2.
Perera T, Thirumangalakudi L, Glennon E, Park S, Insanally M, Persky M, et al.
World J Biol Psychiatry
. 2013 Feb;
14(8):602-10.
PMID: 23398296
Objectives: Although hippocampal neurogenesis has been implicated in mood disorders, the precise role new neurons play in mood regulation is not fully elucidated. Here we examine whether neurogenesis improves mood...
3.
Perera T, Lu D, Thirumangalakudi L, Smith E, Yaretskiy A, Rosenblum L, et al.
Neural Plast
. 2011 Aug;
2011:1-6.
PMID: 21837282
Increased neurogenesis in feeding centers of the murine hypothalamus is associated with weight loss in diet-induced obese rodents (Kokoeva et al., 2005 and Matrisciano et al., 2010), but this relationship...
4.
Perera T, Dwork A, Keegan K, Thirumangalakudi L, Lipira C, Joyce N, et al.
PLoS One
. 2011 Apr;
6(4):e17600.
PMID: 21525974
Background: Rodent studies show that neurogenesis is necessary for mediating the salutary effects of antidepressants. Nonhuman primate (NHP) studies may bridge important rodent findings to the clinical realm since NHP-depression...
5.
Thirumangalakudi L, Rao H, Grammas P
Neurosci Lett
. 2009 Apr;
452(2):172-5.
PMID: 19383433
The pathways that contribute to thrombin-induced neuron death have been incompletely defined. Induction of cyclooxygenase 2 (COX-2), the enzyme that catalyzes the first step in prostaglandin synthesis, promotes neuronal injury....
6.
Rao H, Thirumangalakudi L, Grammas P
Neurosci Lett
. 2008 Dec;
450(3):347-50.
PMID: 19103257
The extent to which neurons proceed into the cell cycle and the mechanisms whereby cell cycle re-entry leads to apoptosis vary in response to agonists. We previously showed upregulation of...
7.
Tripathy D, Thirumangalakudi L, Grammas P
Neurobiol Aging
. 2008 Apr;
31(1):8-16.
PMID: 18440671
Numerous studies demonstrate inflammatory proteins in the brain and microcirculation in Alzheimer's disease (AD) and implicate inflammation in disease pathogenesis. However, emerging literature suggests that neuroinflammation can also be neuroprotective....
8.
Thirumangalakudi L, Prakasam A, Zhang R, Bimonte-Nelson H, Sambamurti K, Kindy M, et al.
J Neurochem
. 2008 Apr;
106(1):475-85.
PMID: 18410513
Recent findings suggest that hypercholesterolemia may contribute to the onset of Alzheimer's disease-like dementia but the underlying mechanisms remain unknown. In this study, we evaluated the cognitive performance in rodent...
9.
Thirumangalakudi L, Yin L, Rao H, Grammas P
J Alzheimers Dis
. 2007 Sep;
11(3):305-11.
PMID: 17851181
Neuronal cell loss is a critical feature of age-related neurodegenerative diseases such as Alzheimer's disease (AD). In the AD brain, a marked increase in pro-inflammatory cytokines and chemokines, including IL-8,...
10.
Tripathy D, Thirumangalakudi L, Grammas P
J Alzheimers Dis
. 2007 Jul;
11(4):447-55.
PMID: 17656823
Inflammatory mediators are highly expressed in the Alzheimer's disease (AD) brain. We have shown that in AD the cerebral microcirculation is a rich source of cytokines and chemokines including interleukins...