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Lakita G Cavin

Explore the profile of Lakita G Cavin including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 8
Citations 220
Followers 0
Related Specialties
Oncology
Cell Biology
Molecular Biology
Top 10 Co-Authors
Marcello Arsura
Ganesh R Panta
Snorri S Thorgeirsson
Swayamjot Kaur
Frank Mercurio
Valentina M Factor
Mervyn Israel
Gail E Sonenshein
Trevor W Sweatman
Jennifer D Bilyeu
Published In
Oncogene
Mol Pharmacol
Cancer Lett
Hepatology
Cancer Res
Affiliations
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Recent Articles
1.
Nuclear-factor-kappaB (NF-kappaB) and radical oxygen species play contrary roles in transforming growth factor-beta1 (TGF-beta1)-induced apoptosis in hepatocellular carcinoma (HCC) cells
Wang F, Kaur S, Cavin L, Arsura M
Biochem Biophys Res Commun . 2008 Nov; 377(4):1107-12. PMID: 18983820
Nuclear-Factor-kappaB (NF-kappaBeta can counteract transforming growth factor-beta1 (TGF-beta1)-induced apoptosis in malignant hepatocytes through up-regulation of its downstream genes, such as X-linked inhibitor of apoptosis protein (XIAP). Reports have demonstrated that...
2.
Nuclear factor-kappaB and liver carcinogenesis
Arsura M, Cavin L
Cancer Lett . 2005 Aug; 229(2):157-69. PMID: 16125305
Hepatocellular carcinoma (HCC) is the third deadliest and fifth most common human cancer worldwide. Hepatitis C virus (HCV) and hepatitis B virus (HBV) infections along with alcohol and aflatoxin B1...
3.
Transforming growth factor-alpha inhibits the intrinsic pathway of c-Myc-induced apoptosis through activation of nuclear factor-kappaB in murine hepatocellular carcinomas
Cavin L, Wang F, Factor V, Kaur S, Venkatraman M, Thorgeirsson S, et al.
Mol Cancer Res . 2005 Jul; 3(7):403-12. PMID: 16046551
Nuclear factor-kappaB (NF-kappaB) plays an important role during liver neoplastic development through transcriptional regulation of prosurvival genes, which then counteract the death-inducing signals elicited by the host immune response. The...
4.
Regulation of alpha-fetoprotein by nuclear factor-kappaB protects hepatocytes from tumor necrosis factor-alpha cytotoxicity during fetal liver development and hepatic oncogenesis
Cavin L, Venkatraman M, Factor V, Kaur S, Schroeder I, Mercurio F, et al.
Cancer Res . 2004 Oct; 64(19):7030-8. PMID: 15466196
Nuclear factor-kappaB (NF-kappaB) plays a critical role during fetal liver development and hepatic oncogenesis. Here, we have assessed whether NF-kappaB activity is required for murine hepatocellular carcinoma cell survival. We...
5.
Circumvention of nuclear factor kappaB-induced chemoresistance by cytoplasmic-targeted anthracyclines
Bilyeu J, Panta G, Cavin L, Barrett C, Turner E, Sweatman T, et al.
Mol Pharmacol . 2004 Mar; 65(4):1038-47. PMID: 15044634
Nuclear factor kappaB (NF-kappaB) has been implicated in inducible chemoresistance against anthracyclines. In an effort to improve the cytotoxicity of anthracyclines while reducing their cardiotoxic effects, we have developed a...
6.
ATM and the catalytic subunit of DNA-dependent protein kinase activate NF-kappaB through a common MEK/extracellular signal-regulated kinase/p90(rsk) signaling pathway in response to distinct forms of DNA damage
Panta G, Kaur S, Cavin L, Cortes M, Mercurio F, Lothstein L, et al.
Mol Cell Biol . 2004 Feb; 24(5):1823-35. PMID: 14966265
We have identified a novel pathway of ataxia telangiectasia mutated (ATM) and DNA-dependent protein kinase (DNA-PK) signaling that results in nuclear factor kappaB (NF-kappaB) activation and chemoresistance in response to...
7.
Inhibition of CK2 activity by TGF-beta1 promotes IkappaB-alpha protein stabilization and apoptosis of immortalized hepatocytes
Cavin L, Romieu-Mourez R, Panta G, Sun J, Factor V, Thorgeirsson S, et al.
Hepatology . 2003 Dec; 38(6):1540-51. PMID: 14647065
Nuclear factor kappaB (NF-kappaB) is an antiapoptotic factor involved in development, regeneration, and neoplastic progression of the liver. Previously, we have shown that stabilization of inhibitor kappaB (IkappaB)-alpha protein following...
8.
Transient activation of NF-kappaB through a TAK1/IKK kinase pathway by TGF-beta1 inhibits AP-1/SMAD signaling and apoptosis: implications in liver tumor formation
Arsura M, Panta G, Bilyeu J, Cavin L, Sovak M, Oliver A, et al.
Oncogene . 2003 Jan; 22(3):412-25. PMID: 12545162
NF-kappaB has been implicated in the regulation of apoptosis, a key mechanism of normal and malignant growth control. Previously, we demonstrated that inhibition of NF-kappaB activity by TGF-beta1 leads directly...