Laiqiang Chen
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Explore the profile of Laiqiang Chen including associated specialties, affiliations and a list of published articles.
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13
Citations
45
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Recent Articles
1.
Zhang Y, Chen X, Chen L, Shao M, Zhu W, Xing T, et al.
Mol Neurodegener
. 2024 Oct;
19(1):75.
PMID: 39425207
Background: The activation of endoplasmic reticulum (ER) stress is an early pathological hallmark of Alzheimer's disease (AD) brain, but how ER stress contributes to the onset and development of AD...
2.
Han R, Wang Q, Xiong X, Chen X, Tu Z, Li B, et al.
J Clin Invest
. 2024 Oct;
134(20).
PMID: 39403921
Parkinson's disease (PD) is characterized by age-dependent neurodegeneration and the accumulation of toxic phosphorylated α-synuclein (pS129-α-syn). The mechanisms underlying these crucial pathological changes remain unclear. Mutations in parkin RBR E3...
3.
Qin Y, Chen L, Zhu W, Song J, Lin J, Li Y, et al.
Sci Adv
. 2024 May;
10(20):eadl2036.
PMID: 38758800
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease characterized by preferential neuronal loss in the striatum. The mechanism underlying striatal selective neurodegeneration remains unclear, making it difficult to develop...
4.
Chen L, Qin Y, Guo T, Zhu W, Lin J, Xing T, et al.
Cell Death Dis
. 2024 May;
15(5):337.
PMID: 38744826
Huntington's disease (HD) is a monogenic neurodegenerative disease, caused by the CAG trinucleotide repeat expansion in exon 1 of the Huntingtin (HTT) gene. The HTT gene encodes a large protein...
5.
Tong H, Yang T, Liu L, Li C, Sun Y, Jia Q, et al.
Neurobiol Dis
. 2023 Sep;
187:106291.
PMID: 37716514
Huntington's disease (HD) is an autosomal-dominant inherited neurodegenerative disease caused by a CAG repeat expansion in exon1 of the huntingtin gene (HTT). This expansion leads to the production of N-terminal...
6.
Yang S, Ma J, Zhang H, Chen L, Li Y, Pan M, et al.
Front Neurosci
. 2023 Aug;
17:1238306.
PMID: 37539389
Introduction: Huntington's disease (HD) is caused by expanded CAG repeats in the huntingtin gene (HTT) and is characterized by late-onset neurodegeneration that primarily affects the striatum. Several studies have shown...
7.
Bai D, Zhu L, Jia Q, Duan X, Chen L, Wang X, et al.
Prog Neurobiol
. 2023 Jun;
227:102484.
PMID: 37315918
TAR binding protein 43 (TDP-43) is normally present in the nucleus but mislocalized in the cytoplasm in a number of neurodegenerative diseases including Huntington's disease (HD). The nuclear loss of...
8.
Zhao X, Sun Y, Wang Z, Chen L, Li S, Li X
Front Cell Neurosci
. 2022 Nov;
16:1021592.
PMID: 36439204
Huntington disease (HD) is caused by the expansion of CAG triplet repeats in exon 1 of the gene, which also encodes the first 17 amino acids (N-17) that can modulate...
9.
Chen X, Sun Y, Chen L, Chen X, Pan M, Zhang Y, et al.
Cell Mol Life Sci
. 2022 Oct;
79(11):554.
PMID: 36251080
Huntingtin-associated protein 1 (HAP1) is the first identified protein whose function is affected by its abnormal interaction with mutant huntingtin (mHTT), which causes Huntington disease. However, the expression patterns of...
10.
Yin P, Bai D, Deng F, Zhang C, Jia Q, Zhu L, et al.
Autophagy
. 2021 Dec;
18(8):1955-1968.
PMID: 34936539
The cytoplasmic accumulation and aggregates of TARDBP/TDP-43 (TAR DNA binding protein) are a pathological hallmark in amyotrophic lateral sclerosis and frontotemporal lobar degeneration. We previously reported that the primate specific...