L Wiesmuller
Overview
Explore the profile of L Wiesmuller including associated specialties, affiliations and a list of published articles.
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27
Citations
1156
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Recent Articles
1.
Asperger H, Cieslik J, Alberter B, Kostler C, Polzer B, Muller V, et al.
Transl Oncol
. 2021 May;
14(8):101132.
PMID: 34051621
Background: Liquid Biopsy (LB) in the form of e.g., circulating tumor cells (CTCs) is a promising non-invasive approach to support current therapeutic cancer management. However, the proof of clinical utility...
2.
Gole B, Mian E, Rall M, Wiesmuller L
Leukemia
. 2017 Jun;
32(1):159-167.
PMID: 28626219
The breakpoint cluster region of the MLL gene (MLLbcr) is frequently rearranged in therapy-related and infant acute leukaemia, but the destabilizing mechanism is poorly understood. We recently proposed that DNA...
3.
Obermeier K, Sachsenweger J, Friedl T, Pospiech H, Winqvist R, Wiesmuller L
Oncogene
. 2015 Dec;
35(29):3796-806.
PMID: 26640152
Hereditary heterozygous mutations in a variety of DNA double-strand break (DSB) repair genes have been associated with increased breast cancer risk. In the Finnish population, PALB2 (partner and localizer of...
4.
Kraft D, Rall M, Volcic M, Metzler E, Groo A, Stahl A, et al.
Leukemia
. 2015 Feb;
29(7):1543-54.
PMID: 25652738
Hematopoietic stem and progenitor cells (HSPC), that is, the cell population giving rise not only to all mature hematopoietic lineages but also the presumed target for leukemic transformation, can transmit...
5.
Gole B, Baumann C, Mian E, Ireno C, Wiesmuller L
Oncogene
. 2014 Aug;
34(26):3391-401.
PMID: 25132265
MLL (myeloid/lymphoid or mixed-lineage leukemia) rearrangements are frequent in therapy-related and childhood acute leukemia, and are associated with poor prognosis. The majority of the rearrangements fall within a 7.3-kb MLL...
6.
Bohringer M, Obermeier K, Griner N, Waldraff D, Dickinson E, Eirich K, et al.
Oncogene
. 2013 Feb;
32(48):5458-70.
PMID: 23435420
BALB/c mice heterozygous for Trp53 develop a high proportion of spontaneous mammary tumors, a phenotype distinct from other mouse strains. BALB/c-Trp53+/- female mice, thus, resemble the hereditary Li-Fraumeni syndrome (LFS)...
7.
Gatz S, Wiesmuller L
Cell Death Differ
. 2006 Mar;
13(6):1003-16.
PMID: 16543940
Convergent studies demonstrated that p53 regulates homologous recombination (HR) independently of its classic tumour-suppressor functions in transcriptionally transactivating cellular target genes that are implicated in growth control and apoptosis. In...
8.
Susse S, Janz C, Janus F, Deppert W, Wiesmuller L
Oncogene
. 2000 Sep;
19(39):4500-12.
PMID: 11002423
Our previous work (Dudenhöffer et al., 1999) unveiled a link between the capacity of p53 to regulate homologous recombination processes and to specifically bind to heteroduplex junction DNAs. Here, we...
9.
Albrechtsen N, Dornreiter I, Grosse F, Kim E, Wiesmuller L, Deppert W
Oncogene
. 2000 Jan;
18(53):7706-17.
PMID: 10618711
In this review we describe the multiple functions of p53 in response to DNA damage, with an emphasis on p53's role in DNA repair. We summarize data demonstrating that p53,...
10.
Dudenhoffer C, Kurth M, Janus F, Deppert W, Wiesmuller L
Oncogene
. 1999 Oct;
18(42):5773-84.
PMID: 10523858
Recently, we described a new biological function of p53 in inhibiting recombination processes when encountering mismatches in heteroduplexes (Dudenhöffer et al., 1998). Here, we characterized protein domains of p53 participating...