L Steven Johnson
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Explore the profile of L Steven Johnson including associated specialties, affiliations and a list of published articles.
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9
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3748
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Recent Articles
1.
Canny S, Reese T, Johnson L, Zhang X, Kambal A, Duan E, et al.
mBio
. 2014 Mar;
5(2):e01033-13.
PMID: 24618256
Pervasive transcription is observed in a wide range of organisms, including humans, mice, and viruses, but the functional significance of the resulting transcripts remains uncertain. Current genetic approaches are often...
2.
Wakeman B, Johnson L, Paden C, Gray K, Virgin H, Speck S
J Virol
. 2014 Feb;
88(10):5474-90.
PMID: 24574412
Unlabelled: The essential immediate early transcriptional activator RTA, encoded by gene 50, is conserved among all characterized gammaherpesviruses. Analyses of a recombinant murine gammaherpesvirus 68 (MHV68) lacking both of the...
3.
Chapa T, Johnson L, Affolter C, Valentine M, Fehr A, Yokoyama W, et al.
J Virol
. 2013 Jun;
87(16):9135-47.
PMID: 23760242
Herpesvirus genes are temporally expressed during permissive infections, but how their expression is regulated at late times is poorly understood. Previous studies indicate that the human cytomegalovirus (CMV) gene, UL79,...
4.
Loh J, Zhao G, Nelson C, Coder P, Droit L, Handley S, et al.
J Virol
. 2011 Jan;
85(6):2642-56.
PMID: 21209105
Gammaherpesviruses encode numerous immunomodulatory molecules that contribute to their ability to evade the host immune response and establish persistent, lifelong infections. As the human gammaherpesviruses are strictly species specific, small...
5.
Johnson L, Eddy S, Portugaly E
BMC Bioinformatics
. 2010 Aug;
11:431.
PMID: 20718988
Background: Profile hidden Markov models (profile-HMMs) are sensitive tools for remote protein homology detection, but the main scoring algorithms, Viterbi or Forward, require considerable time to search large sequence databases....
6.
Identification of novel microRNA-like molecules generated from herpesvirus and host tRNA transcripts
Reese T, Xia J, Johnson L, Zhou X, Zhang W, Virgin H
J Virol
. 2010 Jul;
84(19):10344-53.
PMID: 20660200
We applied deep sequencing technology to small RNA fractions from cells lytically infected with murine gammaherpesvirus 68 (gammaHV68) in order to define in detail small RNAs generated from a cluster...
7.
Johnson L, Willert E, Virgin H
Cell Host Microbe
. 2010 Jun;
7(6):516-26.
PMID: 20542255
Viral genetic studies typically focus on large open reading frames (ORFs) identified during genome annotation (ORF-based annotation). Here we describe tools for examining viral gene expression nucleotide by nucleotide across...
8.
Starostina N, Marshburn S, Johnson L, Eddy S, Terns R, Terns M
Proc Natl Acad Sci U S A
. 2004 Sep;
101(39):14097-101.
PMID: 15375211
Box C/D RNAs are small, noncoding RNAs that function in RNA modification in eukaryotes and archaea. Here, we report that box C/D RNAs exist in the rare biological form of...
9.
Waterston R, Lindblad-Toh K, Birney E, Rogers J, Abril J, Agarwal P, et al.
Nature
. 2002 Dec;
420(6915):520-62.
PMID: 12466850
The sequence of the mouse genome is a key informational tool for understanding the contents of the human genome and a key experimental tool for biomedical research. Here, we report...