L Sistonen
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Explore the profile of L Sistonen including associated specialties, affiliations and a list of published articles.
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59
Citations
1600
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Recent Articles
11.
Soitamo A, Rabergh C, Gassmann M, Sistonen L, Nikinmaa M
J Biol Chem
. 2001 Mar;
276(23):19699-705.
PMID: 11278461
The mammalian hypoxia-inducible factor-1 (HIF-1) is a heterodimeric transcription factor that controls the induction of several genes involved in glycolysis, erythropoiesis, and angiogenesis when cells are exposed to hypoxic conditions....
12.
Kaarniranta K, Holmberg C, Lammi M, Eriksson J, Sistonen L, Helminen H
Osteoarthritis Cartilage
. 2001 Feb;
9(1):7-13.
PMID: 11178942
Objective: During joint loading, chondrocytes in the articular cartilage are subjected to gradients of high compressive hydrostatic pressure (HP). In response to diverse chemical or physical stresses, heat shock genes...
13.
Eriksson M, Jokinen E, Sistonen L, Leppa S
Int J Dev Biol
. 2000 Oct;
44(5):471-7.
PMID: 11032181
Two members of the heat shock transcription factor family, HSF1 and HSF2, have been identified as activators of mammalian heat shock gene expression. HSF1 acts as a classical stress-responsive factor,...
14.
Holmberg C, Illman S, Kallio M, Mikhailov A, Sistonen L
Cell Stress Chaperones
. 2000 Sep;
5(3):219-28.
PMID: 11005380
In concert with the stress-induced activation of human heat shock factor 1 (HSF1), the factor becomes inducibly phosphorylated and accumulates into nuclear granules. To date, these processes are not fully...
15.
Jackson K, Deleon M, Sistonen L, Verret C
Cell Immunol
. 2000 Aug;
203(1):12-8.
PMID: 10915557
A20 lymphoma cells were subjected to heat shock for 2 h at 42 and 43 +/- 0.1 degrees C and then evaluated at 37 degrees C for sensitivity to lysis...
16.
Kaarniranta K, Holmberg C, Helminen H, Eriksson J, Sistonen L, Lammi M
FEBS Lett
. 2000 Jun;
475(3):283-6.
PMID: 10869572
We have recently described that in chondrocytic cells high hydrostatic pressure (HP) causes a heat shock response via mRNA stabilization without a transcriptional activation of the hsp70 gene. In this...
17.
Rabergh C, Airaksinen S, Soitamo A, Bjorklund H, Johansson T, Nikinmaa M, et al.
J Exp Biol
. 2000 May;
203(Pt 12):1817-24.
PMID: 10821739
All organisms respond to environmental, chemical and physiological stresses by enhanced synthesis of an evolutionarily conserved family of proteins known as heat shock proteins (HSPs) or stress proteins. Certain HSPs...
18.
Pirkkala L, Alastalo T, Zuo X, Benjamin I, Sistonen L
Mol Cell Biol
. 2000 Mar;
20(8):2670-5.
PMID: 10733569
Inhibition of proteasome-mediated protein degradation machinery is a potent stress stimulus that causes accumulation of ubiquitinated proteins and increased expression of heat shock proteins (Hsps). Hsps play pivotal roles in...
19.
Pirkkala L, Sistonen L
Cell Stress Chaperones
. 1999 Dec;
4(4):259-61.
PMID: 10590840
No abstract available.
20.
Samali A, Holmberg C, Sistonen L, Orrenius S
FEBS Lett
. 1999 Nov;
461(3):306-10.
PMID: 10567716
We tested the hypothesis that heat shock protein (Hsp) induction and cell death are mutually exclusive responses to stress. Despite activation of heat shock transcription factor 1 at temperatures ranging...