L S Jacobs
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Explore the profile of L S Jacobs including associated specialties, affiliations and a list of published articles.
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85
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Recent Articles
11.
Lorenson M, Jacobs L
Endocrinology
. 1987 Jan;
120(1):365-72.
PMID: 3780568
PRL and GH are stored in bovine pituitary secretory granules in part as intermolecular disulfide-linked multimers (as many as 50 monomers/oligomer). In vitro incubation of granules with reduced glutathione (GSH)...
12.
Jacobs L, Lorenson M
Metabolism
. 1986 Mar;
35(3):209-15.
PMID: 3081777
Little is known about the structure of prolactin (PRL) within secretory granules. Evidence from our previous studies in bovine tissue preparations suggests that control of secretion may reside, in part,...
13.
Brillon D, Nabil N, Jacobs L
Endocr Res
. 1986 Jan;
12(2):137-46.
PMID: 3015580
In order to clarify the roles of cholinergic and serotonergic neurotransmission in the mediation of exercise-induced growth hormone (GH) release, normal young volunteers of both sexes were studied. Exercise was...
14.
Thompson D, Penicaud L, Welle S, Jacobs L
Metabolism
. 1985 Apr;
34(4):383-90.
PMID: 3982277
A group of 14 healthy subjects received 50 mg/kg body weight of 2 deoxy-D-glucose (2DG) IV in a 20-minute infusion to induce glucoprivation and stimulate the release of growth hormone...
15.
Lorenson M, Jacobs L
Endocrinology
. 1984 Oct;
115(4):1492-5.
PMID: 6479100
Cysteamine [2-aminoethanethiol (CySH)] reduces measurable PRL concentrations in vivo and in vitro. Since secretion is also inhibited, CySH may block conversion from a poorly assayable hormone storage form(s) to readily...
16.
Jacobs L, Lorenson M
Endocrinology
. 1984 Sep;
115(3):1210-7.
PMID: 6430683
Analogs of the aminothiol cysteamine (CySH) have been studied to clarify the structural features required for exertion of inhibitory effects on PRL. The inhibited functions examined were the detectability of...
17.
Lorenson M, Jacobs L
Endocrinology
. 1984 Mar;
114(3):717-24.
PMID: 6230223
To assess the role in hormone release of the recently characterized anion-sensitive Mg+2-ATPase of pituitary secretory granules, three types of evidence were accumulated. First, granule suspensions were incubated with varying...
18.
Lorenson M, Jacobs L
Biochim Biophys Acta
. 1984 Jan;
769(2):479-85.
PMID: 6141804
The limiting membranes of pituitary growth hormone and prolactin secretory granules contain a Mg2+-ATPase sensitive to anions. This enzyme is in many ways similar to mitochondrial ATPase. The enzyme was...
19.
Lorenson M, Robson D, Jacobs L
J Biol Chem
. 1983 Jul;
258(14):8618-22.
PMID: 6408091
Divalent cations inhibited in vitro release of growth hormone (GH) and prolactin (PRL) from bovine adenohypophysial secretory granules. Zinc, nickel, and cadmium were most potent, exerting 50% inhibition of protein...
20.
Lorenson M, Robson D, Jacobs L
Endocrinology
. 1983 May;
112(5):1880-2.
PMID: 6403341
The amount of pituitary PRL detected by RIA in extracts of tissue and of secretory granules was augmented by thiols or EDTA in the extractant, and diminished by divalent cations...