L O Narhi
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Explore the profile of L O Narhi including associated specialties, affiliations and a list of published articles.
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83
Citations
848
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Recent Articles
1.
Cao S, Jiao N, Jiang Y, Mire-Sluis A, Narhi L
Pharmeur Bio Sci Notes
. 2010 Feb;
2009(1):73-9.
PMID: 20144454
Biologics represent a large and growing segment of the therapeutic medicinal market. Sub-visible particles present in these products are a product quality attribute and a potential patient safety concern yet...
2.
Callahan W, Narhi L, Kosky A, Treuheit M
Pharm Res
. 2001 Jul;
18(3):261-6.
PMID: 11442262
Purpose: BDNF, a noncovalent homodimer, was modified by covalently attaching polyethylene glycol (PEG) with an average molecular weight of 20kDa to the N-terminal methionine. Stability of modified BDNF (PEG-BDNF) in...
3.
Narhi L, Arakawa T, Aoki K, Wen J, Elliott S, Boone T, et al.
Protein Eng
. 2001 Apr;
14(2):135-40.
PMID: 11297671
Erythropoietin (EPO) derived from Escherichia coli is unstable to elevated temperature and tends to aggregate with time, making it unsuitable for high-resolution structure analysis. The mammalian EPO contains about 40%...
4.
Biere A, Wood S, Wypych J, Steavenson S, Jiang Y, Anafi D, et al.
J Biol Chem
. 2000 Aug;
275(44):34574-9.
PMID: 10942772
Parkinson's disease (PD) is a neurodegenerative disorder that is pathologically characterized by the presence of intracytoplasmic Lewy bodies. Recently, two point mutations in alpha-synuclein were found to be associated with...
5.
Narhi L, Philo J, Sun B, Chang B, Arakawa T
Pharm Res
. 1999 Jul;
16(6):799-807.
PMID: 10397597
Purpose: The present study was performed to examine the effect of solution conditions on the reversibility of the thermal denaturation of megakaryocyte growth and development factor (rHuMGDF). Methods: Changes in...
6.
Caughey D, Narhi L, Kita Y, Meng S, Wen D, Chen W, et al.
J Chromatogr B Biomed Sci Appl
. 1999 Jun;
728(1):49-57.
PMID: 10379656
We have developed specific antibodies against fragments of anaplastic lymphoma kinase (ALK) in order to develop tools for characterizing the expression and biological function of this orphan receptor. The first...
7.
Moellering B, Yoshinaga S, Hui A, Delaney J, Hara S, Narhi L, et al.
Protein Expr Purif
. 1999 May;
16(1):160-70.
PMID: 10336874
Interferon regulatory factor 4 (IRF-4), an intracellular, multidomain protein, is a member of the interferon regulatory factor family and a lymphoid-specific transcription factor that can form a ternary complex with...
8.
Osslund T, Syed R, Singer E, Hsu E, Nybo R, Chen B, et al.
Protein Sci
. 1999 Mar;
7(8):1681-90.
PMID: 10082365
A comprehensive deletion, mutational, and structural analysis of the native recombinant keratinocyte growth factor (KGF) polypeptide has resulted in the identification of the amino acids responsible for its biological activity....
9.
Li T, Narhi L, Wen J, Philo J, Sitney K, Inoue J, et al.
J Protein Chem
. 1999 Feb;
17(8):757-63.
PMID: 9988522
The N-terminal domain (1-318 amino acids) of mouse NFkappaB (p65) has been purified to homogeneity from the soluble fraction of Escherichia coli cells expressing this protein. Its complex with a...
10.
Lu H, Fausset P, Narhi L, Horan T, Shinagawa K, Shimamoto G, et al.
Arch Biochem Biophys
. 1999 Jan;
362(1):1-11.
PMID: 9917323
Chemical modification and mutagenesis of methionines in recombinant human granulocyte colony-stimulating factor (G-CSF) were investigated. Selective oxidation of G-CSF by H2O2 and t-butyl hydroperoxide leads to generation of different oxidized...