L L Cummins
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Explore the profile of L L Cummins including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
557
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Recent Articles
1.
Crooke R, Graham M, Martin M, Lemonidis K, Wyrzykiewiecz T, Cummins L
J Pharmacol Exp Ther
. 1999 Dec;
292(1):140-9.
PMID: 10604941
Phosphorothioate antisense oligodeoxynucleotides are novel therapeutic agents designed to selectively and specifically inhibit production of various disease-related gene products. In vivo pharmacokinetic experiments indicate that these molecules are widely distributed...
2.
Gaus H, Kung P, Brooks D, Cook P, Cummins L
Biotechnol Bioeng
. 1999 Jul;
61(3):169-77.
PMID: 10397804
Capillary electrophoresis has been applied to monitor model reactions in solution-phase combinatorial chemistry. In particular, the simultaneous alkylation reactions of secondary amines with a series of benzyl halides has been...
3.
McKay R, Miraglia L, Cummins L, Owens S, Sasmor H, Dean N
J Biol Chem
. 1999 Jan;
274(3):1715-22.
PMID: 9880552
The use of antisense oligonucleotides to inhibit the expression of targeted mRNA sequences is becoming increasingly commonplace. Although effective, the most widely used oligonucleotide modification (phosphorothioate) has some limitations. In...
4.
Nicklin P, Bayley D, Giddings J, Craig S, Cummins L, Hastewell J, et al.
Pharm Res
. 1998 May;
15(4):583-91.
PMID: 9587955
Purpose: Phosphorothioate antisense oligodeoxynucleotides are promising therapeutic candidates. When given systemically in clinical trials they are administered via slow intravenous infusion to avoid their putative plasma concentration-dependent haemodynamic side-effects. In...
5.
Griffey R, Greig M, Gaus H, Liu K, Monteith D, Winniman M, et al.
J Mass Spectrom
. 1997 Mar;
32(3):305-13.
PMID: 9075339
The pattern of nuclease degradation observed for an antisense phosphorothioate oligonucleotide in pig kidney was determined using liquid chromatography/electrospray mass spectrometry (LC/ESI-MS) and LC/ESI-MS/MS with a quadrupole ion trap mass...
6.
Gaus H, Owens S, Winniman M, Cooper S, Cummins L
Anal Chem
. 1997 Feb;
69(3):313-9.
PMID: 9030048
Metabolism of 2'-deoxyphosphorothioate oligonucleotides ISIS 11061 and ISIS 11637 was examined with capillary gel electrophoresis (CGE) and on-line HPLC electrospray mass spectrometry (HPLC/ES-MS). Oligonucleotides were isolated from plasma, liver, and...
7.
Griffey R, Monia B, Cummins L, Freier S, Greig M, Guinosso C, et al.
J Med Chem
. 1996 Dec;
39(26):5100-9.
PMID: 8978841
Oligonucleotides containing 2'-O-aminopropyl-substituted RNA have been synthesized. The 2'-O-(aminopropyl)adenosine (APA), 2'-O-(aminopropyl)cytidine (APC), 2'-O-(aminopropyl)-guanosine (APG), and 2'-O-(aminopropyl)uridine (APU) have been prepared in high yield from the ribonucleoside, protected, and incorporated into...
8.
Monia B, Johnston J, Sasmor H, Cummins L
J Biol Chem
. 1996 Jun;
271(24):14533-40.
PMID: 8662854
We have previously described structure-activity studies on a 17-mer uniform phosphorothioate antisense sequence targeted to human Ha-ras. In an effort to further improve the pharmacological properties of antisense oligonucleotides, structure-activity...
9.
Crooke S, Graham M, Zuckerman J, Brooks D, Conklin B, Cummins L, et al.
J Pharmacol Exp Ther
. 1996 May;
277(2):923-37.
PMID: 8627575
Biophysical and pharmacokinetic properties of five analogs of ISIS 3082, a 20-mer phosphorothioate oligodeoxynucleotide that inhibits the expression of mouse intercellular adhesion molecule 1, were evaluated. Compared to the parent...
10.
Leeds J, Graham M, Truong L, Cummins L
Anal Biochem
. 1996 Mar;
235(1):36-43.
PMID: 8850544
Methods are presented for the extraction of phosphorothioate oligonucleotides from human plasma to permit quantitation by capillary gel electrophoresis. Extraction of the phosphorothioate oligonucleotides from plasma was accomplished using two...