E A Lesnik
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Explore the profile of E A Lesnik including associated specialties, affiliations and a list of published articles.
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33
Citations
1024
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Recent Articles
1.
Lesnik E, Sampath R, Levene H, Henderson T, McNeil J, Ecker D
Nucleic Acids Res
. 2001 Aug;
29(17):3583-94.
PMID: 11522828
A new algorithm called RNAMotif containing RNA structure and sequence constraints and a thermodynamic scoring system was used to search for intrinsic rho-independent terminators in the Escherichia coli K-12 genome....
2.
Geary R, Watanabe T, Truong L, Freier S, Lesnik E, Sioufi N, et al.
J Pharmacol Exp Ther
. 2001 Feb;
296(3):890-7.
PMID: 11181921
Plasma pharmacokinetics, biodistribution, excretion, and metabolism of four modified 20-mer antisense oligonucleotides targeted to human intercellular adhesion molecule-1 mRNA have been characterized in rats and compared with a first-generation phosphorothioate...
3.
Prakash T, Manoharan M, Kawasaki A, Lesnik E, Owens S, Vasquez G
Org Lett
. 2000 Dec;
2(25):3995-8.
PMID: 11112626
[structure] Oligonucleotides with two novel modifications, 2'-O-¿2-[N, N-(dimethyl)aminooxy]ethyl¿ (2'-O-DMAOE) and 2'-O-¿2-[N, N-(diethyl)aminooxy]ethyl¿ (2'-O-DEAOE), have been synthesized. These modifications exhibit high binding affinity to target RNA (and not to DNA) and...
4.
Balow G, Mohan V, Lesnik E, Johnston J, Monia B, Acevedo O
Nucleic Acids Res
. 1998 Jul;
26(14):3350-7.
PMID: 9649618
The synthesis of 7-propynyl-, 7-iodo- and 7-cyano-7-deaza-2-amino-2'-deoxyadenosines is described. The nucleosides were synthesized, functionalized into the phosphoramidites and incorporated into oligodeoxynucleotides. Spectroscopic melting experiments against complementary RNA showed increases of...
5.
Lesnik E, Freier S
Biochemistry
. 1998 Jun;
37(19):6991-7.
PMID: 9578586
The thermostability of hybrid duplexes with uniformly 2'-methoxy modified DNA strands (D'R and RD'), their unmodified DNA:RNA counterparts (DR and RD), and corresponded RNA:RNA (RR) duplexes for six sequences with...
6.
Baker B, Lot S, Condon T, Lesnik E, Sasmor H, Bennett C
J Biol Chem
. 1997 May;
272(18):11994-2000.
PMID: 9115264
Little is known about the mechanisms that account for inhibition of gene expression by antisense oligonucleotides at the level of molecular cell biology. For this purpose, we have selected potent...
7.
Lesnik E, Risen L, Driver D, Griffith M, Sprankle K, Freier S
Nucleic Acids Res
. 1997 Feb;
25(3):568-74.
PMID: 9016597
Slow kinetics of homopyrimidine PNA binding to single stranded DNA and RNA targets is manifested in significant hysteresis in thermal UV absorption experiments. We have compared temperatures of dissociation (Tdis)...
8.
Monia B, Sasmor H, Johnston J, Freier S, Lesnik E, Muller M, et al.
Proc Natl Acad Sci U S A
. 1996 Dec;
93(26):15481-4.
PMID: 8986837
To determine the mechanism of action responsible for the in vivo antitumor activity of a phosphorothioate antisense inhibitor targeted against human C-raf kinase (ISIS 5132, also known as CGP69846A), a...
9.
Jones G, Lesnik E, Owens S, Risen L, Walker R
Nucleic Acids Res
. 1996 Nov;
24(21):4117-22.
PMID: 8932360
The thermal stabilities of the duplexes formed between 4'-thio-modified oligodeoxynucleotides and their DNA and RNA complementary strands were determined and compared with those of the corresponding unmodified oligodeoxynucleotides. A 16mer...
10.
McKay R, Cummins L, Graham M, Lesnik E, Owens S, Winniman M, et al.
Nucleic Acids Res
. 1996 Feb;
24(3):411-7.
PMID: 8602351
We have previously described the characterization of a 20mer phosphorothioate oligodeoxynucleotide (ISIS 4189) which inhibits murine protein kinase C-alpha (PKC-alpha) gene expression, both in vitro and in vivo. In an...