L K Overton
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Explore the profile of L K Overton including associated specialties, affiliations and a list of published articles.
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15
Citations
523
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Recent Articles
1.
Parham J, Iannone M, Overton L, Hutchins J
Cytotechnology
. 2008 Nov;
28(1-3):147-55.
PMID: 19003416
The goals of this study were to identify mammalian cell lines which could be efficiently transiently-transfected and scaled-up for protein production. The transfection efficiencies of eight cell lines (NSO, NSO-TAg,...
2.
Stuart J, Lee F, Simpson Noel D, Kadwell S, Overton L, Hoffman C, et al.
Biochem Pharmacol
. 2001 Sep;
62(7):933-42.
PMID: 11543729
The interaction of baculovirus expressed rat steroid 5alpha-reductase types 1 and 2 (r5AR1 and r5AR2) with 17beta-N-(2,5-bis(trifluoromethyl)phenyl)carbamoyl-4-aza-5alpha-androst-1-en-3-one (GI198745) was investigated at pH 7 and 37 degrees. This 5alpha-reductase inhibitor was...
3.
Rocque W, Porter D, Barnes J, Dixon E, Lobe D, Su J, et al.
Protein Expr Purif
. 2000 Feb;
18(2):148-59.
PMID: 10686145
Replication of human papillomavirus type11 (HPV11) requires both the E1 and the E2 proteins. E1 is structurally and functionally similar to SV40 large T-antigen and is a DNA helicase/NTPase that...
4.
Moss M, Jin S, Milla M, Bickett D, Burkhart W, Carter H, et al.
Nature
. 1997 Feb;
385(6618):733-6.
PMID: 9034191
Tumour-necrosis factor-alpha (TNF-alpha) is a cytokine that contributes to a variety of inflammatory disease states. The protein exists as a membrane-bound precursor of relative molecular mass 26K which can be...
5.
Moss M, Kuzmic P, Stuart J, Tian G, Peranteau A, Frye S, et al.
Biochemistry
. 1996 Mar;
35(11):3457-64.
PMID: 8639496
We have discovered that 17beta-[N,N-(diethyl)carbamoyl]-6-azaandrost-4-en-3-one is a time-dependent inhibitor of type II 5alpha-reductase, as is the drug finasteride. Unlike finasteride, the 6-aza-steroid is not a time-dependent inhibitor of type I...
6.
Overton L, Patel I, Becherer J, Chandra G, Kost T
Methods Mol Biol
. 1995 Jan;
39:225-42.
PMID: 7620552
No abstract available.
7.
Tian G, Stuart J, Moss M, Domanico P, Bramson H, Patel I, et al.
Biochemistry
. 1994 Mar;
33(8):2291-6.
PMID: 8117686
17 beta-(N-tert-butylcarbamoyl)-4-aza-5 alpha-androstan-1-en-3-one (finasteride), which has been approved for treatment of benign prostatic hyperplasia, is shown here to be a slow time-dependent inhibitor of human steroid 5 alpha-reductase isozyme 1....
8.
de Serres F, Overton L, Sadler B
Mutat Res
. 1992 Sep;
269(1):149-69.
PMID: 1381467
Previous studies on X-ray-induced irreparable adenine-3 mutants (designated ad-3IR), induced in heterokaryon 12 of Neurospora crassa, showed that they were not recessive, and that they demonstrated heterozygous effects in terms...
9.
de Serres F, Overton L, Sadler B
Mutat Res
. 1992 May;
267(1):105-24.
PMID: 1373846
Previous studies on X-ray-induced irreparable adenine-3 mutations (designated [ad-3]IR), induced in heterokaryon 12 of Neurospora crassa, demonstrated that they were not recessive and exhibited heterozygous effects in terms of markedly...
10.
de Serres F, Brockman H, Overton L
Mutat Res
. 1991 Aug;
253(1):21-32.
PMID: 1831243
The mutagenicity of 2-amino-N6-hydroxyadenine (AHA) has been studied in Neurospora crassa by treating a two-component heterokaryon (H-12) and recovering specific-locus mutations induced in the ad-3 region. This assay system permits...