L J Ignarro
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Explore the profile of L J Ignarro including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Sherman M, Wong V, Aeberhard E, Fukuto J, Ignarro L
Redox Rep
. 2016 Jul;
2(5):309-16.
PMID: 27406411
Oxygen (O2)-dependent and O2-independent antimicrobial mechanisms are used by alveolar macrophages (AM) to maintain lung sterility, but these mechanisms are underdeveloped in neonatal AM. Nitric oxide (NO(.)), a more recently...
2.
Meldrum D, Gambone J, Morris M, Esposito K, Giugliano D, Ignarro L
Int J Impot Res
. 2011 Nov;
24(2):61-8.
PMID: 22072232
Oxidative stress and inflammation, which disrupt nitric oxide (NO) production directly or by causing resistance to insulin, are central determinants of vascular diseases including ED. Decreased vascular NO has been...
3.
Crimi E, Ignarro L, Napoli C
Free Radic Res
. 2007 Dec;
41(12):1364-75.
PMID: 18075839
The microcirculation is a complex and integrated system, transporting oxygen and nutrients to the cells. The key component of this system is the endothelium, contributing to the local balance between...
4.
Liguori A, DArmiento F, Palagiano A, Balestrieri M, Williams-Ignarro S, De Nigris F, et al.
BJOG
. 2007 Oct;
114(12):1547-56.
PMID: 17903226
Objective: Maternal hypercholesterolaemia during pregnancy increases lipid peroxidation in mothers and fetuses and programs increased susceptibility to atherosclerosis later in life. The objective of this study was to elucidate the...
5.
Matteo M, Cicinelli E, Baldini D, Cho Y, Ignarro L, Vitarelli A, et al.
Int J Androl
. 2006 Feb;
29(4):441-5.
PMID: 16487405
Gonadotrophin treatment is capable of increasing intratesticular blood flow and improving sperm fertilization potential. A nitric oxide (NO)-mediated mechanism may play a role. This study aimed at evaluating whether the...
6.
Napoli C, Sica V, De Nigris F, Pignalosa O, Condorelli M, Ignarro L, et al.
Am Heart J
. 2004 Jun;
148(1):e5.
PMID: 15215814
Background: Essential hypertension is associated with enhanced LDL oxidation and impaired endothelium-dependent vasodilation. The antioxidant status is linked to the nitric oxide (NO) pathway. Sulfhydryl angiotensin-converting enzyme (ACE) inhibitors inhibit...
7.
Ignarro L
J Physiol Pharmacol
. 2003 Jan;
53(4 Pt 1):503-14.
PMID: 12512688
In retrospect, basic research in the fields of NO and cyclic GMP during the past two decades appears to have followed a logical course beginning with the findings that NO...
8.
Azizzadeh B, Yip H, Blackwell K, Horvath S, Calcaterra T, Buga G, et al.
Laryngoscope
. 2002 Jan;
111(11 Pt 1):1896-900.
PMID: 11801965
Objective: To test whether nitric oxide (NO) enhances the cytotoxicity of cisplatin in a head and neck squamous cell carcinoma (HNSCC) cell line. Background: Cisplatin is one of the most...
9.
Jacobs A, Ignarro L
J Biol Chem
. 2001 Oct;
276(51):47950-7.
PMID: 11602590
The production of nitric oxide by macrophages has been implicated as a host defense mechanism against microbial pathogens and tumor cells. Recent reports have implicated interferon-alpha/beta (IFN-alpha/beta) as an autocrine/paracrine...
10.
Bauer P, Buga G, Ignarro L
Proc Natl Acad Sci U S A
. 2001 Oct;
98(22):12802-7.
PMID: 11592976
The purpose of this study was to determine the involvement of the p42/p44 mitogen-activated protein kinase (MAPK) pathway and induction of p21(waf1/cip1) in the antiproliferative effects of nitric oxide (NO)...