L J Ignarro
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Explore the profile of L J Ignarro including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Kashyap V, Reil T, Moore W, Hoang T, Gelabert H, Byrns R, et al.
J Vasc Surg
. 2001 Aug;
34(2):323-9.
PMID: 11496286
Purpose: The goals of this study were to delineate the time course of endothelial dysfunction after arterial thrombosis, to determine the cause of endothelial dysfunction in this setting, and to...
12.
Wei L, Wu G, Morris Jr S, Ignarro L
Proc Natl Acad Sci U S A
. 2001 Jul;
98(16):9260-4.
PMID: 11470919
Arginase, which exists as the isoforms arginase I and II, catalyzes the hydrolysis of arginine to ornithine and urea. Ornithine is the principal precursor for production of polyamines, which are...
13.
Bauer P, Buga G, Fukuto J, Pegg A, Ignarro L
J Biol Chem
. 2001 Jul;
276(37):34458-64.
PMID: 11461922
Ornithine decarboxylase is the initial and rate-limiting enzyme in the polyamine biosynthetic pathway. Polyamines are found in all mammalian cells and are required for cell growth. We previously demonstrated that...
14.
Ma L, Elliott S, Cirino G, Buret A, Ignarro L, Wallace J
Proc Natl Acad Sci U S A
. 2001 May;
98(11):6470-5.
PMID: 11353854
Bleeding and delayed healing of ulcers are well recognized clinical problems associated with the use of aspirin and other nonsteroidal antiinflammatory drugs, which have been attributed to their antiaggregatory effects...
15.
Napoli C, Ignarro L
Nitric Oxide
. 2001 Apr;
5(2):88-97.
PMID: 11292358
Endothelial dysfunction has been shown in a wide range of vascular disorders including atherosclerosis and related diseases. Here, we examine and address the complex relationship among nitric oxide (NO)-mediated pathways...
16.
Ignarro L, Buga G, Wei L, Bauer P, Wu G, Del Soldato P
Proc Natl Acad Sci U S A
. 2001 Mar;
98(7):4202-8.
PMID: 11259671
The objective of this study was to elucidate the mechanisms by which nitric oxide (NO) inhibits rat aortic smooth muscle cell (RASMC) proliferation. Two products of the arginine-NO pathway interfere...
17.
Napoli C, Cirino G, Del Soldato P, Sorrentino R, Sica V, Condorelli M, et al.
Proc Natl Acad Sci U S A
. 2001 Feb;
98(5):2860-4.
PMID: 11226331
Restenosis is due to neointimal hyperplasia, which occurs in the coronary artery after percutaneous transluminal coronary angioplasty (PTCA). During restenosis, an impairment of nitric oxide (NO)-dependent pathways may occur. Concomitant...
18.
Fiorucci S, Mencarelli A, Palazzetti B, Del Soldato P, Morelli A, Ignarro L
Proc Natl Acad Sci U S A
. 2001 Feb;
98(5):2652-7.
PMID: 11226294
Caspases are key mediators in liver inflammation and apoptosis. In the present study we provide evidence that a nitric oxide (NO) derivative of ursodeoxycholic acid (UDCA), NCX-1000 ([2-(acetyloxy)benzoic acid 3-(nitrooxymethyl)phenyl...
19.
Jayachandran M, Hayashi T, Sumi D, Thakur N, Kano H, Ignarro L, et al.
Biochem Biophys Res Commun
. 2001 Feb;
280(3):589-94.
PMID: 11162560
We determined the existence and role of beta(2)-adrenergic receptor in cultured BAECs through the effect of a beta-blocker having NO releasing action; 3,4-dihydro-8(2-hydroxy-3-isopropylamino)-propoxy-3-nitroxy-2H-1-benzopyran; nipradilol on eNOS and eNOS regulatory protein...
20.
Shah S, Hobbs A, Singh R, Cuevas J, Ignarro L, Chaudhuri G
Am J Physiol Regul Integr Comp Physiol
. 2000 Sep;
279(4):R1478-85.
PMID: 11004018
This study evaluated whether increased release of nitric oxide (NO) from the nitrergic component of the nonadrenergic, noncholinergic (NANC) nerves may be partly responsible for the decrease in gastrointestinal motility...