L J Helman
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Explore the profile of L J Helman including associated specialties, affiliations and a list of published articles.
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72
Citations
1738
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Recent Articles
1.
Kang Z, Yu Y, Zhu Y, Davis S, Walker R, Meltzer P, et al.
Oncogene
. 2013 Dec;
33(50):5697-705.
PMID: 24292683
Agents targeting the insulin-like growth factor-1 receptor (IGF1R) are in clinical development, but, despite some initial success of single agents in sarcoma, response rates are low with brief durations. Thus,...
2.
Yeung C, Ngo V, Grohar P, Arnaldez F, Asante A, Wan X, et al.
Oncogene
. 2013 Jan;
32(47):5429-38.
PMID: 23318429
To identify novel signaling pathways necessary for rhabdomyosarcoma (RMS) survival, we performed a loss-of-function screen using an inducible small hairpin RNA (shRNA) library in an alveolar and an embryonal RMS...
3.
Schayek H, Bentov I, Jacob-Hirsch J, Yeung C, Khanna C, Helman L, et al.
Horm Metab Res
. 2012 Apr;
44(7):511-9.
PMID: 22495974
The insulin-like growth factor-I (IGF-IR) and androgen (AR) receptors are important players in prostate cancer. Functional interactions between the IGF-I and androgen signaling pathways have crucial roles in the progression...
4.
Mayeenuddin L, Yu Y, Kang Z, Helman L, Cao L
Oncogene
. 2010 Sep;
29(48):6367-77.
PMID: 20818434
Insulin-like growth factors (IGFs) and their receptor, IGF-1 receptor (IGF1R), have important roles in growth, development, stress response, aging and cancer. There are many agents that inhibit IGF1R in oncology...
5.
Navid F, Letterio J, Yeung C, Pegtel M, Helman L
Sarcoma
. 2008 Jun;
4(3):93-102.
PMID: 18521287
Purpose. Production of active transforming growth factor-beta (TGF-beta ) by human osteosarcoma may contribute to malignant progression through mechanisms that include induction of angiogenesis, immune suppression and autocrine growth stimulation...
6.
Goletz T, Mackall C, Berzofsky J, Helman L
Sarcoma
. 2008 Jun;
2(2):77-87.
PMID: 18521238
Purpose/results/discussion. Recurrent chromosomal translocations are common features of many human malignancies. While such translocations often serve as diagnostic markers, molecular analysis of these breakpoint regions and the characterization of the...
7.
Wan X, Harkavy B, Shen N, Grohar P, Helman L
Oncogene
. 2006 Sep;
26(13):1932-40.
PMID: 17001314
Rapamycin and several analogs, such as CCI-779 and RAD001, are currently undergoing clinical evaluation as anticancer agents. In this study, we show that inhibition of mammalian target of rapamycin (mTOR)...
8.
Worley B, van den Broeke L, Goletz T, Pendleton C, Daschbach E, Thomas E, et al.
Cancer Res
. 2001 Sep;
61(18):6868-75.
PMID: 11559563
Synovial sarcoma (SS), clear cell sarcoma (CCS), and desmoplastic small round cell tumor (DSRCT) are soft-tissue malignancies occurring primarily in adolescents and young adults. These tumors contain specific chromosomal translocations...
9.
Merino M, Navid F, Christensen B, Toretsky J, Helman L, Cheung N, et al.
J Clin Oncol
. 2001 Aug;
19(16):3649-59.
PMID: 11504746
Purpose: A propensity for hematogenous spread with resulting contamination of autologous cell products complicates cellular therapies for Ewing's sarcoma. We used a new approach to purge artificially contaminated cellular specimens...
10.
Mackall C, Helman L
J Pediatr Hematol Oncol
. 2001 Jul;
23(5):266-7.
PMID: 11464979
No abstract available.