L I Rothblum
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Explore the profile of L I Rothblum including associated specialties, affiliations and a list of published articles.
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70
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1648
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Recent Articles
1.
Hannan K, Sanij E, Rothblum L, Hannan R, Pearson R
Biochim Biophys Acta
. 2012 Nov;
1829(3-4):342-60.
PMID: 23153826
Transcription of the ribosomal RNA genes by the dedicated RNA polymerase I enzyme and subsequent processing of the ribosomal RNA are fundamental control steps in the synthesis of functional ribosomes....
2.
Xie W, Rothblum L
Trends Cardiovasc Med
. 2011 Jan;
3(1):7-11.
PMID: 21244964
A common result of the various stimuli that alter the growth rates of cells is a parallel alteration of the rate of ribosome biogenesis. In many cell types, this mandates...
3.
Zhang P, Rothblum L, Han W, Blasick T, Potdar S, Bonventre J
Kidney Int
. 2007 Dec;
73(5):608-14.
PMID: 18160964
Kidney injury molecule-1 (KIM-1) is a specific histological biomarker for diagnosing early tubular injury on renal biopsies. In this study, KIM-1 expression was quantitated in renal transplant biopsies by immunohistochemistry...
4.
Stefanovsky V, Pelletier G, Hannan R, Gagnon-Kugler T, Rothblum L, Moss T
Mol Cell
. 2001 Dec;
8(5):1063-73.
PMID: 11741541
Ribosomal transcription in mammals is regulated in response to growth, differentiation, disease, and aging, but the mechanisms of this regulation have remained unresolved. We show that epidermal growth factor induces...
5.
Zhang X, Song J, Rothblum L, Lun M, Wang X, Ding F, et al.
Am J Physiol Heart Circ Physiol
. 2001 Oct;
281(5):H2079-88.
PMID: 11668069
The functional consequences of overexpression of rat heart Na+/Ca2+ exchanger (NCX1) were investigated in adult rat myocytes in primary culture. When maintained under continued electrical field stimulation conditions, cultured adult...
6.
Cavanaugh A, Hu Q, Catania J, Avantaggiati M, Rothblum L
Nucleic Acids Res
. 2001 Oct;
29(20):4114-24.
PMID: 11600700
Treatment of NIH 3T3 cells with trichostatin A (TSA), an inhibitor of histone deacetylase (HDAC), resulted in a dose-dependent increase in transcription from a rDNA reporter and from endogenous rRNA...
7.
Biggiogera M, Malatesta M, Amalric F, Rothblum L, Fakan S
J Cell Sci
. 2001 Oct;
114(Pt 17):3199-205.
PMID: 11590246
We carried out a high-resolution ultrastructural analysis of the nucleolus in mouse P815 cells by combining specific DNA and RNA staining, anti-fibrillarin immunolabeling, contrast enhancement by energy filtering TEM and...
8.
Pelletier G, Stefanovsky V, Faubladier M, Savard J, Rothblum L, Cote J, et al.
Mol Cell
. 2000 Dec;
6(5):1059-66.
PMID: 11106745
RNA polymerase I (PolI) transcription is activated by the HMG box architectural factor UBF, which loops approximately 140 bp of DNA into the enhancesome, necessitating major chromatin remodeling. Here we...
9.
Hannan K, Hannan R, Smith S, Jefferson L, Lun M, Rothblum L
Oncogene
. 2000 Oct;
19(43):4988-99.
PMID: 11042686
We have previously demonstrated that the protein encoded by the retinoblastoma susceptibility gene (Rb) functions as a regulator of transcription by RNA polymerase I (rDNA transcription) by inhibiting UBF-mediated transcription....
10.
Hannan K, Kennedy B, Cavanaugh A, Hannan R, Jefferson L, Rothblum L
Oncogene
. 2000 Aug;
19(31):3487-97.
PMID: 10918607
When 3T6 cells are confluent, they withdraw from the cell cycle. Concomitant with cell cycle arrest a significant reduction in RNA polymerase I transcription (80% decrease at 100% confluence) is...