L Gaster
Overview
Explore the profile of L Gaster including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
331
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0
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Recent Articles
1.
Laping N, Grygielko E, Mathur A, Butter S, Bomberger J, Tweed C, et al.
Mol Pharmacol
. 2002 Jun;
62(1):58-64.
PMID: 12065755
Transforming growth factor beta1 (TGF-beta1) is a potent fibrotic factor responsible for the synthesis of extracellular matrix. TGF-beta1 acts through the TGF-beta type I and type II receptors to activate...
2.
Watson J, Roberts C, Scott C, Kendall I, Collin L, Day N, et al.
Br J Pharmacol
. 2001 Jul;
133(6):797-806.
PMID: 11454652
A novel compound, SB-272183 (5-Chloro-2, 3-dihydro-6-[4-methylpiperazin-1-yl]-1[4-pyridin-4-yl]napth-1-ylaminocarbonyl]-1H-indole), has been shown to have high affinity for human 5-HT(1A), 5-HT(1B) and 5-HT(1D) receptors with pK(i) values of 8.0, 8.1 and 8.7 respectively and...
3.
Schlicker E, Fink K, Molderings G, Price G, Duckworth M, Gaster L, et al.
Naunyn Schmiedebergs Arch Pharmacol
. 1997 Sep;
356(3):321-7.
PMID: 9303568
Human cerebral cortical slices and synaptosomes, guinea-pig cerebral cortical slices and human right atrial appendages were used to study the effects of SB-216641, a preferential h5-HT1B receptor ligand, and of...
4.
Price G, Burton M, Collin L, Duckworth M, Gaster L, Gothert M, et al.
Naunyn Schmiedebergs Arch Pharmacol
. 1997 Sep;
356(3):312-20.
PMID: 9303567
Despite only modest homology between h5-HT1B and h5-HT1D receptor amino acid sequences, these receptors display a remarkably similar pharmacology. To date there are few compounds which discriminate between these receptor...
5.
Hagan J, Slade P, Gaster L, Jeffrey P, Hatcher J, Middlemiss D
Eur J Pharmacol
. 1997 Jul;
331(2-3):169-74.
PMID: 9274976
The selective, brain penetrant, 5-HT(1B/D) (formerly 5-HT(1D beta/alpha)) receptor agonist SKF-99101H (3-(2-dimethylaminoethyl)-4-chloro-5-propoxyindole hemifumarate) (30 mg/kg i.p.) causes a dose related fall in rectal temperature in guinea pigs which previous studies...
6.
Roberts C, Price G, Gaster L, Jones B, Middlemiss D, Routledge C
Neuropharmacology
. 1997 Apr;
36(4-5):549-57.
PMID: 9225280
The importance of h5-HT1B receptor selectivity for 5-HT terminal autoreceptor activity was investigated with the selective h5-HT1B receptor ligands SB 219085, SB 220272, SB 224289 and SB 216641. The studies...
7.
Bingham S, King B, Rushant B, Smith M, Gaster L, Sanger G
J Pharm Pharmacol
. 1995 Mar;
47(3):219-22.
PMID: 7602484
The ability of 5-hydroxytryptamine (5-HT) to evoke contractile activity in the gastric Heidenhain pouch was measured in conscious dogs using a method in which 5-HT4 receptor-antagonist activity can be measured...