C Coutelle
Overview
Explore the profile of C Coutelle including associated specialties, affiliations and a list of published articles.
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Articles
188
Citations
1391
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Recent Articles
1.
Wong S, Argyros O, Coutelle C, Harbottle R
Gene Ther
. 2010 Aug;
18(1):82-7.
PMID: 20739959
The ideal gene therapy vector should enable persistent expression without the limitations of safety and reproducibility. We previously reported that a prototype plasmid vector, containing a scaffold matrix attachment region...
2.
Argyros O, Wong S, Niceta M, Waddington S, Howe S, Coutelle C, et al.
Gene Ther
. 2008 Jul;
15(24):1593-605.
PMID: 18633447
An ideal gene therapy vector should enable persistent transgene expression without limitations of safety and reproducibility. Here we report the development of a non-viral episomal plasmid DNA (pDNA) vector that...
3.
Buckley S, Howe S, Sheard V, Ward N, Coutelle C, Thrasher A, et al.
Gene Ther
. 2008 Apr;
15(16):1167-75.
PMID: 18432275
Gene transfer for cystic fibrosis (CF) airway disease has been hampered by the lung's innate refractivity to pathogen infection. We hypothesized that early intervention with an integrating gene transfer vector...
4.
Buckley S, Waddington S, Jezzard S, Bergau A, Themis M, MacVinish L, et al.
Mol Ther
. 2008 Apr;
16(5):819-24.
PMID: 18388933
Due to its early onset and severe prognosis, cystic fibrosis (CF) has been suggested as a candidate disease for in utero gene therapy. In 1997, a study was published claiming...
5.
David A, Peebles D, Gregory L, Waddington S, Themis M, Weisz B, et al.
Hum Gene Ther
. 2006 Jul;
17(7):767-79.
PMID: 16839275
Targeting gene therapy vectors to the fetal intestinal tract could provide a novel means toward prevention of the early postnatal intestinal pathology of cystic fibrosis and other conditions, such as...
6.
David A, Weisz B, Gregory L, Themis M, Cook T, Roubliova X, et al.
Ultrasound Obstet Gynecol
. 2006 Jun;
28(1):82-8.
PMID: 16795134
Objectives: To access the fetal sheep trachea by ultrasound-guided transthoracic injection in order to deliver gene therapy vectors or occlude the trachea with a detachable balloon. Methods: Fetal sheep were...
7.
Bigger B, Siapati E, Mistry A, Waddington S, Nivsarkar M, Jacobs L, et al.
Gene Ther
. 2005 Sep;
13(2):117-26.
PMID: 16163377
Immune responses against an introduced transgenic protein are a potential risk in many gene replacement strategies to treat genetic disease. We have developed a gene delivery approach for hemophilia B...
8.
Coutelle C, Themis M, Waddington S, Buckley S, Gregory L, Nivsarkar M, et al.
Gene Ther
. 2005 Sep;
12(22):1601-7.
PMID: 16136161
Somatic gene delivery in utero is a novel approach to gene therapy for genetic disease based on the hypothesis that prenatal intervention may avoid the development of severe manifestations of...
9.
Buckley S, Waddington S, Jezzard S, Lawrence L, Schneider H, Holder M, et al.
Mol Ther
. 2005 Aug;
12(3):484-92.
PMID: 16099411
Intra-amniotic injection of adenovirus allows transduction of the fetal airways following natural fetal breathing movements. This administration method is promising for use in gene therapy for cystic fibrosis and other...
10.
Waddington S, Kennea N, Buckley S, Gregory L, Themis M, Coutelle C
Gene Ther
. 2004 Sep;
11 Suppl 1:S92-7.
PMID: 15454963
The current approaches to gene therapy of monogenetic diseases into mature organisms are confronted with several problems including the following: (1) the underlying genetic defect may have already caused irreversible...