L Drocourt
Overview
Explore the profile of L Drocourt including associated specialties, affiliations and a list of published articles.
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Articles
6
Citations
269
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Recent Articles
1.
Pascussi J, Gerbal-Chaloin S, Drocourt L, Assenat E, Larrey D, Pichard-Garcia L, et al.
Xenobiotica
. 2005 Jan;
34(7):633-64.
PMID: 15672753
1. Recent investigations on nuclear receptors and other transcription factors involved in the regulation of genes encoding xenobiotic metabolizing and transport systems reveal that xenobiotic-dependent signalling pathways are embedded in,...
2.
Pascussi J, Gerbal-Chaloin S, Drocourt L, Maurel P, Vilarem M
Biochim Biophys Acta
. 2003 Feb;
1619(3):243-53.
PMID: 12573484
Numerous chemicals increase the metabolic capability of organisms by their ability to activate genes encoding various xenochemical-metabolizing enzymes, such as cytochromes P450 (CYPs), transferases and transporters. For example, natural and...
3.
Pascussi J, Drocourt L, Gerbal-Chaloin S, Fabre J, Maurel P, Vilarem M
Eur J Biochem
. 2001 Dec;
268(24):6346-58.
PMID: 11737189
Although CYP3A induction by dexamethasone has been extensively documented, its mechanism is still unclear because both the role of the glucocorticoid receptor and the ability of dexamethasone to activate the...
4.
Drocourt L, Pascussi J, Assenat E, Fabre J, Maurel P, Vilarem M
Drug Metab Dispos
. 2001 Sep;
29(10):1325-31.
PMID: 11560876
The expression of three cytochromes P450 (CYP3A4, CYP2C9, and CYP2B6) was investigated in primary human hepatocyte cultures following treatment with four calcium channel modulators (CCM) of the dihydropyridine family, three...
5.
Pascussi J, Drocourt L, Fabre J, Maurel P, Vilarem M
Mol Pharmacol
. 2000 Jul;
58(2):361-72.
PMID: 10908304
In this report we show that submicromolar concentrations of dexamethasone enhance pregnane X receptor (PXR) activator-mediated CYP3A4 gene expression in cultured human hepatocytes. Because this result is only observed after...
6.
Pascussi J, Jounaidi Y, Drocourt L, Domergue J, Balabaud C, Maurel P, et al.
Biochem Biophys Res Commun
. 1999 Jul;
260(2):377-81.
PMID: 10403778
Pregnane X Receptor (PXR) has been recently shown to regulate the inducible expression of CYP3A genes in response to xenobiotics and steroids. PXR forms a heterodimer with the retinoic acid...