L D Sibley
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Explore the profile of L D Sibley including associated specialties, affiliations and a list of published articles.
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Recent Articles
11.
Hakansson S, Charron A, Sibley L
EMBO J
. 2001 Jun;
20(12):3132-44.
PMID: 11406590
Rapid discharge of secretory organelles called rhoptries is tightly coupled with host cell entry by the protozoan parasite Toxoplasma gondii. Rhoptry contents were deposited in clusters of vesicles within the...
12.
Sibley L, Andrews N
Traffic
. 2001 Feb;
1(2):100-6.
PMID: 11208090
While some intracellular pathogens invade and replicate exclusively in phagocytic host cells, others have evolved mechanisms to stimulate their uptake by cells not equipped with a well-developed phagocytic machinery. A...
13.
Carruthers V, Giddings O, Sibley L
Cell Microbiol
. 2001 Feb;
1(3):225-35.
PMID: 11207555
Toxoplasma gondii is an obligate intracellular parasite that actively invades a wide variety of vertebrate cells, although the basis of its pervasive cell invasion is not completely understood. Here, we...
14.
Brecht S, Carruthers V, Ferguson D, Giddings O, Wang G, Jakle U, et al.
J Biol Chem
. 2000 Oct;
276(6):4119-27.
PMID: 11053441
The initial stage of invasion by apicomplexan parasites involves the exocytosis of the micronemes-containing molecules that contribute to host cell attachment and penetration. MIC4 was previously described as a protein...
15.
Carruthers V, Hakansson S, Giddings O, Sibley L
Infect Immun
. 2000 Jun;
68(7):4005-11.
PMID: 10858215
Toxoplasma gondii is an obligate intracellular parasite that actively invades a wide variety of vertebrate cells, although the basis of this pervasive cell recognition is not understood. We demonstrate here...
16.
Carruthers V, Sherman G, Sibley L
J Biol Chem
. 2000 May;
275(19):14346-53.
PMID: 10799515
MIC2 is an adhesive protein that participates in host cell invasion by the obligate intracellular parasite Toxoplasma gondii. Earlier studies established that MIC2 is secreted into the culture medium by...
17.
Lovett J, Howe D, Sibley L
Mol Biochem Parasitol
. 2000 Mar;
107(1):33-43.
PMID: 10717300
Thrombospondin-related anonymous protein (TRAP) family members participate in attachment and invasion of host cells by apicomplexan parasites. A TRAP homologue in Neospora caninum strain Nc-1 (NcMIC2) was cloned, sequenced and...
18.
Sibley L, Mordue D, Howe D
Immunobiology
. 2000 Jan;
201(2):210-24.
PMID: 10631570
Toxoplasma gondii is a widespread protozoan parasite that causes severe disease only in immunocompromised individuals. Equipped with excellent animal models and relatively advanced systems for genetics, T. gondii provides an...
19.
Howe D, Sibley L
Int J Parasitol
. 1999 Dec;
29(10):1489-96.
PMID: 10608434
The Apicomplexa are a diverse group of parasitic protozoa with very ancient phylogenetic roots. Consistent with their phylogeny, the extant species share conserved proteins and traits that were found in...
20.
Mordue D, Desai N, Dustin M, Sibley L
J Exp Med
. 1999 Dec;
190(12):1783-92.
PMID: 10601353
The protozoan parasite Toxoplasma gondii actively penetrates its host cell by squeezing through a moving junction that forms between the host cell plasma membrane and the parasite. During invasion, this...