L C McPhail
Overview
Explore the profile of L C McPhail including associated specialties, affiliations and a list of published articles.
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58
Citations
1309
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Recent Articles
1.
Sergeant S, Waite K, Heravi J, McPhail L
J Biol Chem
. 2000 Nov;
276(7):4737-46.
PMID: 11078731
In human neutrophils, the activation of phospholipase D and the Tyr phosphorylation of proteins are early signaling events upon cell stimulation. We found that the pretreatment of neutrophils with ethanol...
2.
Palicz A, Foubert T, Jesaitis A, Marodi L, McPhail L
J Biol Chem
. 2000 Nov;
276(5):3090-7.
PMID: 11060300
The enzyme NADPH oxidase is regulated by phospholipase D in intact neutrophils and is activated by phosphatidic acid (PA) plus diacylglycerol (DG) in cell-free systems. We showed previously that cell-free...
3.
Regier D, GREENE D, Sergeant S, Jesaitis A, McPhail L
J Biol Chem
. 2000 Jul;
275(37):28406-12.
PMID: 10893420
Human neutrophils participate in the host innate immune response, partly mediated by the multicomponent superoxide-generating enzyme NADPH oxidase. A correlation between phosphorylation of cytosolic NADPH oxidase components and enzyme activation...
4.
Karlsson A, Nixon J, McPhail L
J Leukoc Biol
. 2000 Mar;
67(3):396-404.
PMID: 10733101
The neutrophil NADPH-oxidase can be activated by protein kinase C (PKC) agonists such as phorbol myristate acetate (PMA), resulting in superoxide anion release. This superoxide release is independent of phosphatidylinositol...
5.
Regier D, Waite K, Wallin R, McPhail L
J Biol Chem
. 1999 Dec;
274(51):36601-8.
PMID: 10593961
Using a phosphorylation-dependent cell-free system to study NADPH oxidase activation (McPhail, L. C., Qualliotine-Mann, D., and Waite, K. A. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 7931-7935), we...
6.
Nixon J, McPhail L
J Immunol
. 1999 Oct;
163(8):4574-82.
PMID: 10510401
The responses of human neutrophils (PMN) involve reorganization and phosphorylation of cytoskeletal components. We investigated the translocation of protein kinase C (PKC) isoforms to PMN cytoskeletal (Triton-insoluble) fractions, in conjunction...
7.
McPhail L, Waite K, Regier D, Nixon J, Zhang W, Wallin R, et al.
Biochim Biophys Acta
. 1999 Jul;
1439(2):277-90.
PMID: 10425401
Activation of phospholipase D occurs in response to a wide variety of hormones, growth factors, and other extracellular signals. The initial product of phospholipase D, phosphatidic acid (PA), is thought...
8.
Sergeant S, McPhail L
J Immunol
. 1997 Sep;
159(6):2877-85.
PMID: 9300711
We examined the ability of opsonized zymosan (OPZ) to stimulate translocation of protein kinase C (PKC) isoforms in human neutrophils. Neutrophils express five PKC isoforms (alpha, betaI, betaII, delta, and...
9.
Waite K, Wallin R, McPhail L
J Biol Chem
. 1997 Jun;
272(24):15569-78.
PMID: 9182594
Phosphatidic acid (PA), generated by phospholipase D activation, has been linked to the activation of the neutrophil respiratory burst enzyme, NADPH oxidase; however, the intracellular enzyme targets for PA remain...
10.
Kent J, Sergeant S, Burns D, McPhail L
J Immunol
. 1996 Nov;
157(10):4641-7.
PMID: 8906844
The intracellular mechanisms that regulate the function of human neutrophils are not well understood. Receptor-initiated signaling events result in the production of several second messengers (e.g., Ca2+, diacylglycerol, phosphatidic acid,...