L Bosca
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Explore the profile of L Bosca including associated specialties, affiliations and a list of published articles.
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129
Citations
1863
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Recent Articles
1.
Brea R, Motino O, Frances D, Garcia-Monzon C, Vargas J, Fernandez-Velasco M, et al.
Biochim Biophys Acta Mol Basis Dis
. 2017 Nov;
1864(2):325-337.
PMID: 29109031
MicroRNAs (miRNAs), small noncoding RNAs modulating messenger RNA (mRNA) and protein expression, have emerged as key regulatory molecules in chronic liver diseases, whose end stage is hepatic fibrosis, a major...
2.
Gonzalez-Rodriguez A, Mayoral R, Agra N, Valdecantos M, Pardo V, Miquilena-Colina M, et al.
Cell Death Dis
. 2014 Apr;
5:e1179.
PMID: 24743734
The pathogenic mechanisms underlying the progression of non-alcoholic fatty liver disease (NAFLD) are not fully understood. In this study, we aimed to assess the relationship between endoplasmic reticulum (ER) stress...
3.
Traves P, Pardo V, Pimentel-Santillana M, Gonzalez-Rodriguez A, Mojena M, Rico D, et al.
Cell Death Dis
. 2014 Mar;
5:e1125.
PMID: 24625984
Inhibition of protein tyrosine phosphatase 1B (PTP1B) has been suggested as an attractive target to improve insulin sensitivity in different cell types. In the present work, we have investigated the...
4.
Fernandez-Alvarez A, Llorente-Izquierdo C, Mayoral R, Agra N, Bosca L, Casado M, et al.
Oncogenesis
. 2013 Apr;
1:e23.
PMID: 23552739
Cyclooxygenases (COX-1 and 2) catalyze the first step in prostanoid biosynthesis. They are implicated in homeostatic processes with an important role in inflammation and carcinogenesis. In the liver, COX-2 expression...
5.
Traves P, Lopez-Fontal R, Cuadrado I, Luque A, Bosca L, De Las Heras B, et al.
Oncogene
. 2012 Feb;
32(2):259-68.
PMID: 22310289
Labdane diterpenoids have a broad spectrum of biological activities including antibacterial, antiviral and anti-inflammatory properties. However, little is known about their possible role in the apoptotic cell death machinery. Here,...
6.
Cuadrado I, Fernandez-Velasco M, Bosca L, De Las Heras B
Cell Death Dis
. 2011 Nov;
2:e229.
PMID: 22071634
Several labdane diterpenes exert anti-inflammatory and cytoprotective actions; therefore, we have investigated whether these molecules protect cardiomyocytes in an anoxia/reperfusion (A/R) model, establishing the molecular mechanisms involved in the process....
7.
Faine L, Rudnicki M, Cesar F, Heras B, Bosca L, Souza E, et al.
Curr Med Chem
. 2011 Jul;
18(22):3351-60.
PMID: 21728966
Thiazolidinediones (TZDs) are a class of drugs used for treatment of type 2 diabetes. However, the therapy with currently available TDZs (e.g. rosiglitazone) is associated with important side effects, such...
8.
Prieto P, Cuenca J, Traves P, Fernandez-Velasco M, Martin-Sanz P, Bosca L
Cell Death Differ
. 2010 Jan;
17(7):1179-88.
PMID: 20094061
Lipoxin A(4) (LXA(4)) is an endogenous lipid mediator that requires transcellular metabolic traffic for its synthesis. The targets of LXA(4) on neutrophils are well described, contributing to attenuation of inflammation....
9.
Pedrosa A, Faine L, Grosso D, De Las Heras B, Bosca L, Abdalla D
Biochim Biophys Acta
. 2009 Dec;
1801(4):430-7.
PMID: 20005974
The aim of this study was to determine the apoptotic pathways and mechanisms involved in electronegative LDL [LDL(-)]-induced apoptosis in RAW 264.7 macrophages and the role of Nrf2 in this...
10.
Kaurane diterpenes protect against apoptosis and inhibition of phagocytosis in activated macrophages
De Las Heras B, Hortelano S, Giron N, Bermejo P, Rodriguez B, Bosca L
Br J Pharmacol
. 2007 Jul;
152(2):249-55.
PMID: 17618303
Background And Purpose: The kaurane diterpenes foliol and linearol are inhibitors of the activation of nuclear factor kappaB, a transcription factor involved in the inflammatory response. Effects of these diterpenes...