Kyle R Spinler
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Explore the profile of Kyle R Spinler including associated specialties, affiliations and a list of published articles.
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11
Citations
1843
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Recent Articles
1.
Alvey C, Spinler K, Irianto J, Pfeifer C, Hayes B, Xia Y, et al.
Curr Biol
. 2017 Jul;
27(14):2065-2077.e6.
PMID: 28669759
Marrow-derived macrophages are highly phagocytic, but whether they can also traffic into solid tumors and engulf cancer cells is questionable, given the well-known limitations of tumor-associated macrophages (TAMs). Here, SIRPα...
2.
Nair P, Karthick S, Spinler K, Vakili M, Lavasanifar A, Discher D
Nanomedicine (Lond)
. 2016 May;
11(12):1551-69.
PMID: 27177319
Aim: In order to improve the delivery of aromatic drugs by micellar assemblies, and particularly by long and flexible filomicelles, aromatic groups were integrated into the hydrophobic block of a...
3.
Sosale N, Spinler K, Alvey C, Discher D
Curr Opin Immunol
. 2015 Jul;
35:107-12.
PMID: 26172292
Professional phagocytes of the mononuclear phagocyte system (MPS), especially ubiquitous macrophages, are commonly thought to engulf or not a target based strictly on 'eat me' molecules such as Antibodies. The...
4.
Spinler K, Shin J, Lambert M, Discher D
Blood
. 2014 Nov;
125(3):525-33.
PMID: 25395423
Megakaryocyte ploidy and the generation of pre/proplatelets are both increased in culture by pharmacologic inhibition of myosin-II, but nonmuscle myosin-IIA (MIIA) mutations paradoxically cause MYH9-related diseases (MYH9-RD) that adversely affect...
5.
Buxboim A, Swift J, Irianto J, Spinler K, Dingal P, Athirasala A, et al.
Curr Biol
. 2014 Aug;
24(16):1909-17.
PMID: 25127216
Tissue microenvironments are characterized not only in terms of chemical composition but also by collective properties such as stiffness, which influences the contractility of a cell, its adherent morphology, and...
6.
Harada T, Swift J, Irianto J, Shin J, Spinler K, Athirasala A, et al.
J Cell Biol
. 2014 Feb;
204(5):669-82.
PMID: 24567359
Cell migration through solid tissue often involves large contortions of the nucleus, but biological significance is largely unclear. The nucleoskeletal protein lamin-A varies both within and between cell types and...
7.
Shin J, Buxboim A, Spinler K, Swift J, Christian D, Hunter C, et al.
Cell Stem Cell
. 2013 Nov;
14(1):81-93.
PMID: 24268694
Self-renewal and differentiation of stem cells depend on asymmetric division and polarized motility processes that in other cell types are modulated by nonmuscle myosin-II (MII) forces and matrix mechanics. Here,...
8.
Shin J, Spinler K, Swift J, Chasis J, Mohandas N, Discher D
Proc Natl Acad Sci U S A
. 2013 Nov;
110(47):18892-7.
PMID: 24191023
Hematopoietic stem and progenitor cells, as well as nucleated erythroblasts and megakaryocytes, reside preferentially in adult marrow microenvironments whereas other blood cells readily cross the endothelial barrier into the circulation....
9.
Swift J, Ivanovska I, Buxboim A, Harada T, Dingal P, Pinter J, et al.
Science
. 2013 Aug;
341(6149):1240104.
PMID: 23990565
Tissues can be soft like fat, which bears little stress, or stiff like bone, which sustains high stress, but whether there is a systematic relationship between tissue mechanics and differentiation...
10.
Shin J, Swift J, Ivanovska I, Spinler K, Buxboim A, Discher D
Differentiation
. 2013 Jun;
86(3):77-86.
PMID: 23790394
Adult stem cells and progenitors are of great interest for their clinical application as well as their potential to reveal deep sensitivities to microenvironmental factors. The bone marrow is a...