Kurt Dejgaard
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Explore the profile of Kurt Dejgaard including associated specialties, affiliations and a list of published articles.
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15
Citations
372
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0
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Recent Articles
1.
Tsamchoe M, Lazaris A, Kim D, Krzywon L, Bloom J, Mayer T, et al.
BJC Rep
. 2024 Nov;
1(1):8.
PMID: 39516397
Background: Metastasis is the principal cause of cancer treatment failure and an area of dire diagnostic needs. Colorectal cancer metastases to the liver (CRCLMs) are predominantly classified into desmoplastic and...
2.
Khayachi A, Abuzgaya M, Liu Y, Jiao C, Dejgaard K, Schorova L, et al.
EBioMedicine
. 2024 May;
104:105161.
PMID: 38772282
Background: Bipolar disorder (BD) is a multifactorial psychiatric illness affecting ∼1% of the global adult population. Lithium (Li), is the most effective mood stabilizer for BD but works only for...
3.
Hsiao J, Penalva Y, Yee-Li Wu H, Xiao B, Jansen G, Dejgaard K, et al.
Biochemistry
. 2023 Mar;
62(6):1209-1218.
PMID: 36857408
The physiological functions of the rhomboid-related protein 4 (RHBDL4) are emerging, but their molecular details remain unclear. Because increased expression of RHBDL4 has been clinically linked to poorer outcomes in...
4.
Dufour C, Xia H, Bchir W, Perry M, Kuzmanov U, Gainullina A, et al.
Commun Biol
. 2022 Sep;
5(1):955.
PMID: 36097051
Functional oncogenic links between ErbB2 and ERRα in HER2+ breast cancer patients support a therapeutic benefit of co-targeted therapies. However, ErbB2 and ERRα also play key roles in heart physiology,...
5.
Paquette M, El-Houjeiri L, Zirden L, Puustinen P, Blanchette P, Jeong H, et al.
Autophagy
. 2021 Mar;
17(12):3957-3975.
PMID: 33734022
Increased macroautophagy/autophagy and lysosomal activity promote tumor growth, survival and chemo-resistance. During acute starvation, autophagy is rapidly engaged by AMPK (AMP-activated protein kinase) activation and MTOR (mechanistic target of rapamycin...
6.
Brahimi F, Galan A, Jmaeff S, Barcelona P, De Jay N, Dejgaard K, et al.
iScience
. 2020 Aug;
23(9):101447.
PMID: 32829283
Events at a receptor ectodomain affect the intracellular domain conformation, activating signal transduction (out-to-in conformational effects). We investigated the reverse direction (in-to-out) where the intracellular domain may impact on ectodomain...
7.
Waller D, Jansen G, Golizeh M, Martel-Lorion C, Dejgaard K, Shiao T, et al.
Chembiochem
. 2016 Jan;
17(9):843-51.
PMID: 26792008
The unfolded protein response (UPR) initiated by the transmembrane kinase/ribonuclease Ire1 has been implicated in a variety of diseases. Ire1, with its unique position in the UPR, is an ideal...
8.
Matthes E, Goepp J, Carlile G, Luo Y, Dejgaard K, Billet A, et al.
Br J Pharmacol
. 2015 Oct;
173(3):459-70.
PMID: 26492939
Background And Purpose: The most common cystic fibrosis (CF) mutation F508del inhibits the gating and surface expression of CFTR, a plasma membrane anion channel. Optimal pharmacotherapies will probably require both...
9.
McCall L, Zhang W, Dejgaard K, Atayde V, Mazur A, Ranasinghe S, et al.
J Proteome Res
. 2014 Dec;
14(2):1033-59.
PMID: 25536015
Leishmaniasis is a neglected tropical disease caused by Leishmania protozoa. Two main forms are found in the Old World, self-limited cutaneous leishmaniasis and potentially fatal visceral leishmaniasis, with parasite dissemination...
10.
Leclerc D, Dejgaard K, Mazur A, Deng L, Wu Q, Nilsson T, et al.
Proteomics
. 2014 Aug;
14(21-22):2558-65.
PMID: 25081070
Colorectal cancer risk is increased when dietary folate intake is low, with or without a deficiency in methylenetetrahydrofolate reductase (MTHFR). We have observed that intestinal tumors are induced in mice...