Jason C Young
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Explore the profile of Jason C Young including associated specialties, affiliations and a list of published articles.
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53
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2502
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Recent Articles
1.
Rodina A, Xu C, Digwal C, Joshi S, Patel Y, Santhaseela A, et al.
Nat Commun
. 2023 Jun;
14(1):3742.
PMID: 37353488
Systems-level assessments of protein-protein interaction (PPI) network dysfunctions are currently out-of-reach because approaches enabling proteome-wide identification, analysis, and modulation of context-specific PPI changes in native (unengineered) cells and tissues are...
2.
Hsiao J, Penalva Y, Yee-Li Wu H, Xiao B, Jansen G, Dejgaard K, et al.
Biochemistry
. 2023 Mar;
62(6):1209-1218.
PMID: 36857408
The physiological functions of the rhomboid-related protein 4 (RHBDL4) are emerging, but their molecular details remain unclear. Because increased expression of RHBDL4 has been clinically linked to poorer outcomes in...
3.
Franco J, Nogueira M, Gandelini G, Pinheiro G, Goncalves C, Barbosa L, et al.
Biopolymers
. 2023 Feb;
114(2):e23532.
PMID: 36825649
Perturbations in the native structure, often caused by stressing cellular conditions, not only impair protein function but also lead to the formation of aggregates, which can accumulate in the cell...
4.
Dabbaghizadeh A, Pare A, Cheng-Boivin Z, Dagher R, Minotti S, Dicaire M, et al.
Int J Mol Sci
. 2022 Dec;
23(24).
PMID: 36555380
Autosomal Recessive Spastic Ataxia of the Charlevoix Saguenay (ARSACS) is caused by mutation in the SACS gene resulting in loss of function of the protein sacsin. A key feature is...
5.
Young J, Lynch R, Boakye-Achampong S, Jowaisas C, Sam J, Norlander B
GeoJournal
. 2021 Nov;
86(5):2227-2243.
PMID: 34720355
The world is awash in data-by 2020 it is expected that there will be approximately 40 trillion gigabytes of data in existence, with that number doubling every 2 to 3 ...
6.
Goncalves C, Sharon I, Schmeing T, Ramos C, Young J
Sci Rep
. 2021 Aug;
11(1):17139.
PMID: 34429462
In human cells under stress conditions, misfolded polypeptides can form potentially cytotoxic insoluble aggregates. To eliminate aggregates, the HSP70 chaperone machinery extracts and resolubilizes polypeptides for triage to refolding or...
7.
Brahimi F, Galan A, Jmaeff S, Barcelona P, De Jay N, Dejgaard K, et al.
iScience
. 2020 Aug;
23(9):101447.
PMID: 32829283
Events at a receptor ectodomain affect the intracellular domain conformation, activating signal transduction (out-to-in conformational effects). We investigated the reverse direction (in-to-out) where the intracellular domain may impact on ectodomain...
8.
Baaklini I, Goncalves C, Lukacs G, Young J
Sci Rep
. 2020 Mar;
10(1):4176.
PMID: 32144307
Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) channel cause cystic fibrosis. Chaperones, including HSC70, DNAJA1 and DNAJA2, play key roles in both the folding and degradation of wild-type...
9.
Robertson R, Conte T, Dicaire M, Rymar V, Sadikot A, Bryson-Richardson R, et al.
Am J Pathol
. 2020 Jan;
190(3):554-562.
PMID: 31953038
BCL-2-associated athanogene 3 (BAG3) is a co-chaperone to heat shock proteins important in degrading misfolded proteins through chaperone-assisted selective autophagy. The recurrent dominant BAG3-P209L mutation results in a severe childhood-onset...
10.
Kim Chiaw P, Hantouche C, Wong M, Matthes E, Robert R, Hanrahan J, et al.
PLoS One
. 2019 Aug;
14(8):e0220984.
PMID: 31408507
Cystic Fibrosis is caused by mutations in the CFTR anion channel, many of which cause its misfolding and degradation. CFTR folding depends on the Hsc70 and Hsp70 chaperones and their...