Kristina Young
Overview
Explore the profile of Kristina Young including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
280
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Recent Articles
1.
Medler T, Kramer G, Bambina S, Gunderson A, Alice A, Blair T, et al.
Sci Rep
. 2023 Apr;
13(1):6277.
PMID: 37072485
Tissue resident memory (Trm) CD8 T cells infiltrating tumors represent an enriched population of tumor antigen-specific T cells, and their presence is associated with improved outcomes in patients. Using genetically...
2.
Bell R, Gough M, Crittenden M, Young K
J Clin Invest
. 2022 Sep;
132(18).
PMID: 36106641
Patients with HPV-unrelated head and neck squamous cell carcinoma (HPV-unrelated HNSCC) show only modest benefit from treatment with PD-1 inhibitors (PD-1i). Targeting transforming growth factor β (TGF-β) may make PD-1i...
3.
4.
Osborne B, Bestelmeyer B, Currier C, Homyak P, Throop H, Young K, et al.
New Phytol
. 2022 Jun;
236(1):15-20.
PMID: 35706381
Drylands, which cover > 40% of Earth's terrestrial surface, are dominant drivers of global biogeochemical cycling and home to more than one third of the global human population. Climate projections...
5.
Leidner R, Crittenden M, Young K, Xiao H, Wu Y, Couey M, et al.
J Immunother Cancer
. 2021 May;
9(5).
PMID: 33963014
Background: Checkpoint inhibitors targeting programmed death receptor-1 (PD-1) have been tested in the neoadjuvant setting for the treatment of locoregionally advanced head and neck squamous cell carcinoma (HNSCC); however, response...
6.
Bernard B, Rajamanickam V, Dubay C, Piening B, Alonso E, Jutric Z, et al.
PLoS One
. 2020 Sep;
15(8):e0238380.
PMID: 32866185
Pancreatic adenocarcinoma is characterized by a complex tumor environment with a wide diversity of infiltrating stromal and immune cell types that impact the tumor response to conventional treatments. However, even...
7.
Monjazeb A, Schalper K, Villarroel-Espindola F, Nguyen A, Shiao S, Young K
Semin Radiat Oncol
. 2020 May;
30(2):145-157.
PMID: 32381294
A malignant tumor consists of malignant cells as well as a wide array of normal host tissues including stroma, vasculature, and immune infiltrate. The interaction between cancer and these host...
8.
Crittenden M, Baird J, Friedman D, Savage T, Uhde L, Alice A, et al.
Oncotarget
. 2016 Sep;
7(48):78653-78666.
PMID: 27602953
Radiation therapy provides a means to kill large numbers of cancer cells in a controlled location resulting in the release of tumor-specific antigens and endogenous adjuvants. However, by activating pathways...
9.
Crocenzi T, Cottam B, Newell P, Wolf R, Hansen P, Hammill C, et al.
J Immunother Cancer
. 2016 Aug;
4:45.
PMID: 27532020
Background: Preclinical studies have shown synergy between radiation therapy and immunotherapy. However, in almost all preclinical models, radiation is delivered in single doses or short courses of high doses (hypofractionated...
10.
Crittenden M, Savage T, Cottam B, Baird J, Rodriguez P, Newell P, et al.
Radiat Res
. 2014 Jul;
182(2):182-90.
PMID: 24992164
An accumulating body of evidence demonstrates that radiation therapy can generate adaptive immune responses that contribute to tumor control. However, in the absence of additional immune therapy, the adaptive immune...