Shelly Bambina
Overview
Explore the profile of Shelly Bambina including associated specialties, affiliations and a list of published articles.
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26
Citations
1467
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Recent Articles
1.
Kramer G, Blair T, Bambina S, Kaur A, Alice A, Baird J, et al.
Sci Rep
. 2024 May;
14(1):11909.
PMID: 38789721
T cells recirculate through tissues and lymphatic organs to scan for their cognate antigen. Radiation therapy provides site-specific cytotoxicity to kill cancer cells but also has the potential to eliminate...
2.
Medler T, Kramer G, Bambina S, Gunderson A, Alice A, Blair T, et al.
Sci Rep
. 2023 Apr;
13(1):6277.
PMID: 37072485
Tissue resident memory (Trm) CD8 T cells infiltrating tumors represent an enriched population of tumor antigen-specific T cells, and their presence is associated with improved outcomes in patients. Using genetically...
3.
Blair T, Baird J, Bambina S, Kramer G, Gostissa M, Harvey C, et al.
Sci Rep
. 2022 Sep;
12(1):14954.
PMID: 36056093
Multiple preclinical studies have shown improved outcomes when radiation therapy is combined with immune modulating antibodies. However, to date, many of these promising results have failed to translate to successful...
4.
Blair T, Bambina S, Kramer G, Dowdell A, Alice A, Baird J, et al.
Life Sci Alliance
. 2022 Apr;
5(9).
PMID: 35487695
Radiation therapy generates extensive cancer cell death capable of promoting tumor-specific immunity. Within the tumor, conventional dendritic cells (cDCs) are known to carry tumor-associated antigens to the draining lymph node...
5.
Alice A, Kramer G, Bambina S, Bahjat K, Gough M, Crittenden M
Sci Rep
. 2021 Aug;
11(1):16347.
PMID: 34381163
Gamma-delta (γδ) T cells express T cell receptors (TCR) that are preconfigured to recognize signs of pathogen infection. In primates, γδ T cells expressing the Vγ9Vδ2 TCR innately recognize (E)-4-hydroxy-3-methyl-but-...
6.
Sharon S, Duhen T, Bambina S, Baird J, Leidner R, Bell B, et al.
Front Oncol
. 2021 Jul;
11:611365.
PMID: 34221953
Patients exhibit distinct responses to immunotherapies that are thought to be linked to their tumor immune environment. However, wide variations in outcomes are also observed in patients with matched baseline...
7.
Sharon S, Baird J, Bambina S, Kramer G, Blair T, Jensen S, et al.
Oncotarget
. 2021 Jul;
12(13):1201-1213.
PMID: 34194619
Surgical resection of head and neck squamous-cell carcinoma (HNSCC) is associated with high rates of local and distant recurrence, partially mitigated by adjuvant therapy. A pre-existing immune response in the...
8.
Blair T, Bambina S, Alice A, Kramer G, Medler T, Baird J, et al.
J Immunol
. 2020 Apr;
204(12):3416-3424.
PMID: 32341058
Radiation therapy is capable of directing adaptive immune responses against tumors by stimulating the release of endogenous adjuvants and tumor-associated Ags. Within the tumor, conventional type 1 dendritic cells (cDC1s)...
9.
Tormoen G, Blair T, Bambina S, Kramer G, Baird J, Rahmani R, et al.
Int J Radiat Oncol Biol Phys
. 2020 Apr;
108(1):93-103.
PMID: 32311417
Purpose: The role of MerTK, a member of the Tyro3-Axl-MerTK family of receptor tyrosine kinase, in the immune response to radiation therapy (RT) is unclear. We investigated immune-mediated tumor control...
10.
Gunderson A, Yamazaki T, McCarty K, Phillips M, Alice A, Bambina S, et al.
PLoS One
. 2019 Feb;
14(2):e0211117.
PMID: 30726287
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic stroma with a poor lymphocyte infiltrate, in part driven by cancer-associated fibroblasts (CAFs). CAFs, which express fibroblast activation protein (FAP), contribute...