Kristina Sakers
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Explore the profile of Kristina Sakers including associated specialties, affiliations and a list of published articles.
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13
Citations
325
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Recent Articles
1.
Wang S, Baumert R, Sejourne G, Bindu D, Dimond K, Sakers K, et al.
bioRxiv
. 2024 Sep;
PMID: 39253496
Astrocytes, a major glial cell type of the brain, regulate synapse numbers and function. However, whether astrocyte dysfunction can cause synaptic pathologies in neurological disorders such as Parkinson's Disease (PD)...
2.
Irala D, Wang S, Sakers K, Nagendren L, Ulloa Severino F, Bindu D, et al.
Neuron
. 2024 Apr;
112(10):1657-1675.e10.
PMID: 38574730
Astrocytes strongly promote the formation and maturation of synapses by secreted proteins. Several astrocyte-secreted synaptogenic proteins controlling excitatory synapse development were identified; however, those that induce inhibitory synaptogenesis remain elusive....
3.
δ-Catenin controls astrocyte morphogenesis via layer-specific astrocyte-neuron cadherin interactions
Tan C, Bindu D, Hardin E, Sakers K, Baumert R, Ramirez J, et al.
J Cell Biol
. 2023 Sep;
222(11).
PMID: 37707499
Astrocytes control the formation of specific synaptic circuits via cell adhesion and secreted molecules. Astrocyte synaptogenic functions are dependent on the establishment of their complex morphology. However, it is unknown...
4.
Ulloa Severino F, Lawal O, Sakers K, Wang S, Kim N, Friedman A, et al.
Nat Commun
. 2023 Sep;
14(1):5522.
PMID: 37684234
Synaptogenesis is essential for circuit development; however, it is unknown whether it is critical for the establishment and performance of goal-directed voluntary behaviors. Here, we show that operant conditioning via...
5.
Irala D, Wang S, Sakers K, Nagendren L, Ulloa-Severino F, Bindu D, et al.
bioRxiv
. 2023 Apr;
PMID: 37066164
Astrocytes strongly promote the formation and maturation of synapses by secreted proteins. To date, several astrocyte-secreted synaptogenic proteins controlling different stages of excitatory synapse development have been identified. However, the...
6.
Activity-dependent translation dynamically alters the proteome of the perisynaptic astrocyte process
Sapkota D, Kater M, Sakers K, Nygaard K, Liu Y, Koester S, et al.
Cell Rep
. 2022 Oct;
41(3):111474.
PMID: 36261025
Within eukaryotic cells, translation is regulated independent of transcription, enabling nuanced, localized, and rapid responses to stimuli. Neurons respond transcriptionally and translationally to synaptic activity. Although transcriptional responses are documented...
7.
Sakers K, Liu Y, Llaci L, Lee S, Vasek M, Rieger M, et al.
Nat Commun
. 2021 Mar;
12(1):1537.
PMID: 33750804
Quaking RNA binding protein (QKI) is essential for oligodendrocyte development as myelination requires myelin basic protein mRNA regulation and localization by the cytoplasmic isoforms (e.g., QKI-6). QKI-6 is also highly...
8.
Parker K, Pedersen C, Gomez A, Spangler S, Walicki M, Feng S, et al.
Cell
. 2019 Jul;
178(3):653-671.e19.
PMID: 31348890
Nociceptin and its receptor are widely distributed throughout the brain in regions associated with reward behavior, yet how and when they act is unknown. Here, we dissected the role of...
9.
Sakers K, Eroglu C
Curr Opin Neurobiol
. 2019 Apr;
57:163-170.
PMID: 30991196
Neuroligins are a family of cell adhesion molecules, which are best known for their functions as postsynaptic components of the trans-synaptic neurexin-neuroligin complexes. Neuroligins are highly conserved across evolution with...
10.
Thompson R, Lake A, Kenny P, Saunders M, Sakers K, Iyer N, et al.
Stem Cells Dev
. 2017 Aug;
26(22):1597-1611.
PMID: 28851266
Central nervous system injury often leads to functional impairment due, in part, to the formation of an inhibitory glial scar following injury that contributes to poor regeneration. Astrocytes are the...