Kristina Najjar
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Explore the profile of Kristina Najjar including associated specialties, affiliations and a list of published articles.
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10
Citations
287
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Recent Articles
1.
Kondow-McConaghy H, Muthukrishnan N, Erazo-Oliveras A, Najjar K, Juliano R, Pellois J
ACS Chem Biol
. 2020 Aug;
15(9):2355-2363.
PMID: 32786263
Cell-penetrating peptides (CPPs) are routinely used for the delivery of macromolecules into live human cells. To enter the cytosolic space of cells, CPPs typically permeabilize the membrane of endosomes. In...
2.
Allen J, Najjar K, Erazo-Oliveras A, Kondow-McConaghy H, Brock D, Graham K, et al.
ACS Chem Biol
. 2019 Oct;
14(12):2641-2651.
PMID: 31633910
Ineffective cellular delivery is a common problem in numerous biological applications. Developing delivery reagents that work robustly in a variety of experimental settings remains a challenge. Herein, we report how...
3.
Brock D, Kustigian L, Jiang M, Graham K, Wang T, Erazo-Oliveras A, et al.
Traffic
. 2018 Mar;
19(6):421-435.
PMID: 29582528
Various densely charged polycationic species, whether of biological or synthetic origin, can penetrate human cells, albeit with variable efficiencies. The molecular underpinnings involved in such transport remain unclear. Herein, we...
4.
Najjar K, Erazo-Oliveras A, Mosior J, Whitlock M, Rostane I, Cinclair J, et al.
Bioconjug Chem
. 2017 Oct;
28(12):2932-2941.
PMID: 29065262
Endosomal entrapment is a common bottleneck in various macromolecular delivery approaches. Recently, the polycationic peptide dfTAT was identified as a reagent that induces the efficient leakage of late endosomes and,...
5.
Najjar K, Erazo-Oliveras A, Brock D, Wang T, Pellois J
J Biol Chem
. 2016 Dec;
292(3):847-861.
PMID: 27923812
Cell-penetrating peptides (CPPs) are well established as delivery agents for otherwise cell-impermeable cargos. CPPs can also theoretically be used to modulate intracellular processes. However, their susceptibility to proteolytic degradation often...
6.
Erazo-Oliveras A, Najjar K, Truong D, Wang T, Brock D, Prater A, et al.
Cell Chem Biol
. 2016 May;
23(5):598-607.
PMID: 27161484
Endosomal entrapment is a severely limiting bottleneck in the delivery of biologics into cells. The compound dfTAT was recently found to circumvent this problem by mediating endosomal leakage efficiently and...
7.
Wang T, Sun Y, Muthukrishnan N, Erazo-Oliveras A, Najjar K, Pellois J
J Biol Chem
. 2016 Feb;
291(15):7902-14.
PMID: 26888085
Arginine-rich peptides can penetrate cells and consequently be used as delivery agents in various cellular applications. The activity of these reagents is often context-dependent, and the parameters that impact cell...
8.
Najjar K, Erazo-Oliveras A, Pellois J
J Vis Exp
. 2015 Sep;
(103).
PMID: 26382730
Macromolecular delivery strategies typically utilize the endocytic pathway as a route of cellular entry. However, endosomal entrapment severely limits the efficiency with which macromolecules penetrate the cytosolic space of cells....
9.
Erazo-Oliveras A, Najjar K, Dayani L, Wang T, Johnson G, Pellois J
Nat Methods
. 2014 Jun;
11(8):861-7.
PMID: 24930129
We report that a tetramethylrhodamine-labeled dimer of the cell-penetrating peptide TAT, dfTAT, penetrates live cells by escaping from endosomes with high efficiency. By mediating endosomal leakage, dfTAT also delivers proteins...
10.
Robinson B, Khurana S, Pohl J, Li W, Ghezzi A, Cady A, et al.
PLoS One
. 2012 May;
7(5):e37394.
PMID: 22624024
Drosophila melanogaster has proven to be a useful model system for the genetic analysis of ethanol-associated behaviors. However, past studies have focused on the response of the adult fly to...