Kristiina Rajamaki
Overview
Explore the profile of Kristiina Rajamaki including associated specialties, affiliations and a list of published articles.
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25
Citations
1221
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Recent Articles
1.
Martin S, Katainen R, Taira A, Valimaki N, Ristimaki A, Seppala T, et al.
Hum Mol Genet
. 2024 Aug;
33(21):1858-1872.
PMID: 39180486
Microsatellite unstable colorectal cancer (MSI-CRC) can arise through germline mutations in mismatch repair (MMR) genes in individuals with Lynch syndrome (LS), or sporadically through promoter methylation of the MMR gene...
2.
Verhagen M, Joosten R, Schmitt M, Valimaki N, Sacchetti A, Rajamaki K, et al.
Nat Genet
. 2024 Jun;
56(7):1456-1467.
PMID: 38902475
According to conventional views, colon cancer originates from stem cells. However, inflammation, a key risk factor for colon cancer, has been shown to suppress intestinal stemness. Here, we used Paneth...
3.
Nurmi K, Silventoinen K, Keskitalo S, Rajamaki K, Kouri V, Kinnunen M, et al.
Cell Rep Med
. 2024 Apr;
5(4):101503.
PMID: 38593810
In monogenic autoinflammatory diseases, mutations in genes regulating innate immune responses often lead to uncontrolled activation of inflammasome pathways or the type I interferon (IFN-I) response. We describe a mechanism...
4.
Verhagen M, Joosten R, Schmitt M, Valimaki N, Sacchetti A, Rajamaki K, et al.
bioRxiv
. 2023 Oct;
PMID: 37873142
According to conventional views, colon cancer originates from stem cells. However, inflammation, a key risk factor for colon cancer, was shown to suppress intestinal stemness. Here, we employed Paneth cells...
5.
Taira A, Palin K, Kuosmanen A, Valimaki N, Kuittinen O, Kuismin O, et al.
Clin Epigenetics
. 2023 Jan;
15(1):7.
PMID: 36639817
Background: Accurate regulation of DNA methylation is necessary for normal cells to differentiate, develop and function. TET2 catalyzes stepwise DNA demethylation in hematopoietic cells. Mutations in the TET2 gene predispose...
6.
Kuisma H, Bramante S, Rajamaki K, Sipila L, Kaasinen E, Kaukomaa J, et al.
Nat Commun
. 2021 Sep;
12(1):5448.
PMID: 34521855
Mechanical forces in a constrained cellular environment were recently established as a facilitator of chromosomal damage. Whether this could contribute to tumorigenesis is not known. Uterine leiomyomas are common neoplasms...
7.
Berta D, Kuisma H, Valimaki N, Raisanen M, Jantti M, Pasanen A, et al.
Nature
. 2021 Aug;
596(7872):398-403.
PMID: 34349258
One in four women suffers from uterine leiomyomas (ULs)-benign tumours of the uterine wall, also known as uterine fibroids-at some point in premenopausal life. ULs can cause excessive bleeding, pain...
8.
Olkinuora A, Peltomaki P, Aaltonen L, Rajamaki K
Hum Mol Genet
. 2021 Jul;
30(R2):R206-R224.
PMID: 34329396
Hereditary colorectal cancer (CRC) syndromes attributable to high penetrance mutations represent 9-26% of young-onset CRC cases. The clinical significance of many of these mutations is understood well enough to be...
9.
Rajamaki K, Taira A, Katainen R, Valimaki N, Kuosmanen A, Plaketti R, et al.
Gastroenterology
. 2021 Apr;
161(2):592-607.
PMID: 33930428
Background & Aims: Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory disorder associated with an elevated risk of colorectal cancer (CRC). IBD-associated CRC (IBD-CRC) may represent a distinct pathway...
10.
Kondelin J, Martin S, Katainen R, Renkonen-Sinisalo L, Lepisto A, Koskensalo S, et al.
Genes Chromosomes Cancer
. 2021 Feb;
60(7):463-473.
PMID: 33527622
Microsatellite instability (MSI) is caused by defective DNA mismatch repair (MMR), and manifests as accumulation of small insertions and deletions (indels) in short tandem repeats of the genome. Another form...