Kristian M Muller
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Explore the profile of Kristian M Muller including associated specialties, affiliations and a list of published articles.
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53
Citations
522
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Recent Articles
1.
Goett-Zink L, Karsten L, Mann C, Horstmeier H, Spang J, Muller K, et al.
J Am Chem Soc
. 2025 Mar;
PMID: 40054855
In-cell experiments on proteins have revealed that the cellular environment can exert a considerable influence on protein mechanism and structure. Here, we introduce in-cell infrared difference spectroscopy (ICIRD) as a...
2.
Radukic M, Le D, Krassuski T, Borchert P, Leach D, Muller K
Nucleic Acids Res
. 2024 Dec;
53(2.
PMID: 39657764
Current plasmid propagation in E. coli compromises large inverted repeats, such as inverted terminal repeats (ITRs) of adeno-associated virus (AAV). Direct long-read sequencing analyses upon varying strains and culture conditions...
3.
Kotschnew K, Winkler D, Reckmann J, Mann C, Schweigert A, Tellkamp G, et al.
Eur J Cell Biol
. 2024 Oct;
103(4):151461.
PMID: 39406055
During intracellular trafficking N-ethylmaleimide-sensitive-factor attachment receptor (SNARE) proteins catalyze the membrane fusion by assembling into a four-helix complex. In the mouse model, loss of the endosomal SNAREs vti1a and vti1b...
4.
Golm S, Hubner W, Muller K
Viruses
. 2023 May;
15(5).
PMID: 37243260
Research on adeno-associated virus (AAV) and its recombinant vectors as well as on fluorescence microscopy imaging is rapidly progressing driven by clinical applications and new technologies, respectively. The topics converge,...
5.
Le D, Radukic M, Teschner K, Becker L, Muller K
ACS Synth Biol
. 2022 Oct;
11(11):3601-3607.
PMID: 36279242
Virus-like particles (VLPs) have been used for numerous pharmaceutical applications, particularly vaccination and drug delivery. Recombinant adeno-associated virus (rAAV), a leading candidate in gene therapy, has been proposed as a...
6.
Karsten L, Goett-Zink L, Schmitz J, Hoffrogge R, Grunberger A, Kottke T, et al.
Biosensors (Basel)
. 2022 May;
12(5).
PMID: 35624572
pH-sensitive fluorescent proteins as genetically encoded pH sensors are promising tools for monitoring intra- and extracellular pH. However, there is a lack of ratiometric pH sensors, which offer a good...
7.
Karsten L, Janson N, Le Joncour V, Alam S, Muller B, Tanjore Ramanathan J, et al.
Int J Mol Sci
. 2022 Mar;
23(5).
PMID: 35269611
Epidermal growth factor receptor (EGFR) is a validated tumor marker overexpressed in various cancers such as squamous cell carcinoma (SSC) of the head and neck and gliomas. We constructed protein-drug...
8.
Gruss H, Feiner R, Mseya R, Schroder D, Jewginski M, Muller K, et al.
Beilstein J Org Chem
. 2022 Jan;
18:1-12.
PMID: 35047078
The development of peptide stapling techniques to stabilise α-helical secondary structure motifs of peptides led to the design of modulators of protein-protein interactions, which had been considered undruggable for a...
9.
Boschanski M, Kruger T, Karsten L, Falck G, Alam S, Gerlach M, et al.
Bioconjug Chem
. 2021 Jun;
32(6):1167-1174.
PMID: 34060308
Multiple, site-specific protein conjugation is increasingly attractive for the generation of antibody-drug conjugates (ADCs). As it is important to control the number and position of cargoes in an ADC, position-selective...
10.
Le D, Muller K
Life (Basel)
. 2021 Apr;
11(4).
PMID: 33920215
Virus-like particles (VLPs) are increasingly used for vaccine development and drug delivery. Assembly of VLPs from purified monomers in a chemically defined reaction is advantageous compared to in vivo assembly,...