Kristen E Shannon
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Explore the profile of Kristen E Shannon including associated specialties, affiliations and a list of published articles.
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8
Citations
91
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Recent Articles
1.
Rowbottom M, Bain G, Calderon I, Lasof T, Lonergan D, Lai A, et al.
J Med Chem
. 2017 May;
60(10):4403-4423.
PMID: 28471663
LOXL2 catalyzes the oxidative deamination of ε-amines of lysine and hydroxylysine residues within collagen and elastin, generating reactive aldehydes (allysine). Condensation with other allysines or lysines drives the formation of...
2.
Bain G, Shannon K, Huang F, Darlington J, Goulet L, Prodanovich P, et al.
J Pharmacol Exp Ther
. 2016 Oct;
360(1):1-13.
PMID: 27754931
Autotaxin (ATX) is a secreted glycoprotein that converts lysophosphatidylcholine (LPC) to the bioactive phospholipid lysophosphatidic acid (LPA) and is the major enzyme generating circulating LPA. Inhibition of LPA signaling has...
3.
Nagarajan S, Devadas B, Malecha J, Lu H, Ruminski P, Rico J, et al.
Bioorg Med Chem
. 2007 Apr;
15(11):3783-800.
PMID: 17399986
The integrin alpha(v)beta(3), vitronectin receptor, is expressed in a number of cell types and has been shown to mediate adhesion of osteoclasts to bone matrix, vascular smooth muscle cell migration,...
4.
Nagarajan S, Lu H, Gasiecki A, Khanna I, Parikh M, Desai B, et al.
Bioorg Med Chem
. 2007 Mar;
15(10):3390-412.
PMID: 17387018
The integrin alpha(v)beta(3) is expressed in a number of cell types and is thought to play a major role in several pathological conditions. Various small molecules that inhibit the integrin...
5.
Penning T, Khilevich A, Chen B, Russell M, Boys M, Wang Y, et al.
Bioorg Med Chem Lett
. 2006 Apr;
16(12):3156-61.
PMID: 16621534
We describe a series of pyrazole and isoxazole analogs as antagonists of the alpha(v)beta3 receptor. Compounds showed low to sub-nanomolar potency against alpha(v)beta3, as well as good selectivity against alpha(IIb)beta3....
6.
Wendt J, Wu H, Stenmark H, Boys M, Downs V, Penning T, et al.
Bioorg Med Chem Lett
. 2005 Nov;
16(4):845-9.
PMID: 16303301
We describe a series of 2,5 thiazole containing compounds, which are potent antagonists of the integrin alpha(v)beta3 and show selectivity relative to the other integrins, such as alpha(IIb)beta3 and alpha(v)beta6....
7.
Shannon K, Keene J, Settle S, Duffin T, Nickols M, Westlin M, et al.
Clin Exp Metastasis
. 2004 Jun;
21(2):129-38.
PMID: 15168730
Integrins expressed on endothelial cells modulate cell migration and survival during angiogenesis. Integrins expressed on carcinoma cells potentiate metastasis by facilitating invasion and movement across blood vessels. We describe the...
8.
Penning T, Russell M, Chen B, Chen H, Desai B, Docter S, et al.
Bioorg Med Chem Lett
. 2004 Mar;
14(6):1471-6.
PMID: 15006384
We describe a series of conformationally-restricted cinnamic acid peptidomimetics as well as several cinnamic acid isosteres, including 3-phenylpropionic acids, 2-amino-3-phenylpropionic acids, phenoxyacetic acids and 2-phenylcyclopropylcarboxylic acids. Several analogues demonstrated low...