Krishna R Iyer
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Explore the profile of Krishna R Iyer including associated specialties, affiliations and a list of published articles.
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6
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10
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Recent Articles
1.
Khan A, Poojary S, Bhave K, Nandan S, Iyer K, Coutinho E
ACS Omega
. 2022 Jun;
7(21):18094-18102.
PMID: 35664614
It has always been a challenge to develop interventional therapies for . Over the years, several attempts at developing such therapies have hit a dead-end owing to rapid mutation rates...
2.
Borkar M, Martis E, Nandan S, Patil R, Shelar A, Iyer K, et al.
Chem Biol Interact
. 2021 Nov;
351:109758.
PMID: 34826397
We report the synthesis and in vitro evaluation of 1,3-disubstituted-4-hydroxy-6-methylpyridin-2(1H)-one derivatives against Leishmania donovani. Amongst the compound library synthesized, molecules 3d, 3f, 3h, 3i, 3l, and 3m demonstrated substantial dose-dependent...
3.
Subash S, Gogtay N, Iyer K, Gandhe P, Budania R, Thatte U
Indian J Pharmacol
. 2021 Jun;
53(3):213-220.
PMID: 34169906
Background: Aldehyde oxidase (AO), a molybdoflavoenzyme, is emerging as a key player in drug discovery and metabolism. Despite having several known substrates, there are no validated probes reported for studying...
4.
Satish S, Chitral R, Kori A, Sharma B, Puttur J, Khan A, et al.
Mol Divers
. 2021 Jan;
26(1):73-96.
PMID: 33385288
N-furfuryl piperazine ureas disclosed by scientists at GSK Tres Cantos were chosen as antimycobacterial hits from a phenotypic whole-cell screen. Bioisosteric replacement of the furan ring in the GSK Tres...
5.
Wavhale R, Martis E, Ambre P, Wan B, Franzblau S, Iyer K, et al.
Bioorg Med Chem
. 2017 Aug;
25(17):4835-4844.
PMID: 28778369
BM212 [1,5-diaryl-2-methyl-3-(4-methylpiperazin-1-yl)-methyl-pyrrole] is a pyrrole derivative with strong inhibitory activity against drug resistant Mycobacterium tuberculosis and mycobacteria residing in macrophages. However, it was not pursued because of its poor pharmacokinetics...
6.
Martis E, Chandarana R, Shaikh M, Ambre P, DSouza J, Iyer K, et al.
J Biomol Struct Dyn
. 2014 Jun;
33(5):1107-25.
PMID: 24905476
There is a need for continued development of acetylcholinesterase (AChE) inhibitors that could prolong the life of acetylcholine in the synaptic cleft and also prevent the aggregation of amyloid peptides...