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» Authors » Raghuvir R S Pissurlenkar

Raghuvir R S Pissurlenkar

Explore the profile of Raghuvir R S Pissurlenkar including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 31
Citations 131
Followers 0
Related Specialties
Biochemistry
Chemistry
Molecular Biology
Top 10 Co-Authors
Evans C Coutinho
Basir Ahmad
Mushtaque S Shaikh
Vijay M Khedkar
Shivani A Muthu
Deepika Maliwal
Sonali M Shiriskar
Pravin C Mhaske
Premlata K Ambre
Renu Chadha
Published In
J Biomol Struct Dyn
Med Chem
Mol Divers
Carbohydr Polym
J Mol Model
Affiliations
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Recent Articles
1.
New thiazolyl-isoxazole derivatives as potential anti-infective agents: design, synthesis, and antimicrobial efficacy
Bhoye M, Shinde A, Shaikh A, Shisode V, Chavan A, Maliwal D, et al.
J Biomol Struct Dyn . 2024 Jan; :1-15. PMID: 38258445
Antimicrobial resistance threatens the efficacious prevention and treatment of infectious diseases caused by microorganisms. To combat microbial infections, the need for new drug candidates is essential. In this context, the...
2.
Investigations for the Identification of Novel Inhibitors Targeting Hepatitis C Virus RNA-dependent RNA Polymerase
Mallya S, Pissurlenkar R
Med Chem . 2023 Oct; 20(1):52-62. PMID: 37815178
Background: Hepatitis C is an inflammatory condition of the liver caused by the hepatitis C virus, exhibiting acute and chronic manifestations with severity ranging from mild to severe and lifelong...
3.
Comprehensive computational study in the identification of novel potential cholesterol lowering agents targeting proprotein convertase subtilisin/kexin type 9
Maliwal D, Pissurlenkar R, Telvekar V
J Biomol Struct Dyn . 2023 Jun; 42(9):4656-4667. PMID: 37309035
The enzymatic target (PCSK9) is critically involved in the regulation of the lipoprotein metabolism leading to the degradation of low-density lipoprotein receptors (LDLRs) upon binding. Drugs that lower LDL cholesterol...
4.
Synthesis, biological screening and in silico studies of new N-phenyl-4-(1,3-diaryl-1H-pyrazol-4-yl)thiazol-2-amine derivatives as potential antifungal and antitubercular agents
Nandurkar Y, Bhoye M, Maliwal D, Pissurlenkar R, Chavan A, Katade S, et al.
Eur J Med Chem . 2023 Jun; 258:115548. PMID: 37307623
A new series of N-aryl-4-(1,3-diaryl-1H-pyrazol-4-yl)thiazol-2-amine, (8a-x) have been synthesized by a cyclo-condensation reaction of 2-bromo-1-(1,3-diphenyl-1H-pyrazol-4-yl)ethanone (6a-f) with N-aryl thiourea, (7a-d). The structure of newly synthesized N-aryl-4-(1,3-diaryl-1H-pyrazol-4-yl)thiazol-2-amine, (8a-x) derivatives was analyzed...
5.
The cocrystal of 3-((4-(3-isocyanobenzyl) piperazine-1-yl) methyl) benzonitrile with 5-hydroxy isophthalic acid prevents protofibril formation of serum albumin
Shabbir S, Muslim M, Muthu S, Pissurlenkar R, Fatima S, Ali A, et al.
J Biomol Struct Dyn . 2020 Sep; 40(1):538-548. PMID: 32876543
The formation of amyloid-like fibrils is a central problem in biophysical chemistry and medicine. Fibril formation and their deposition in various tissues and organs are associated with many human diseases....
6.
The reorganization of conformations, stability and aggregation of serum albumin isomers through the interaction of glycopeptide antibiotic teicoplanin: A thermodynamic and spectroscopy study
Muthu S, Jadav H, Srivastava S, Pissurlenkar R, Ahmad B
Int J Biol Macromol . 2020 Jul; 163:66-78. PMID: 32615213
The drugs-protein binding study is of growing importance for drug-repurposing against amyloidosis. In this work, we study the binding of teicoplanin (TPN), a glycopeptide antibiotic, with bovine serum albumin (BSA)...
7.
Size-Induced Chiral Discrimination Switching by (S)-(-)-2(α-Hydroxyethyl)Benzimidazole-Derived Azacrowns
Pandey A, Mohammed H, Pissurlenkar R, Karnik A
Chempluschem . 2020 Jan; 80(3):475-479. PMID: 31973411
(S)-(-)-2-(α-Hydroxyethyl)benzimidazole (1)-derived diastereomeric monoaza-[18]crown-6 compounds 5 and 6 were synthesised with an additional chiral centre bearing a phenyl ring. The aim was to achieve enhanced enantioselective discrimination, compared with monoaza-[15]crown-5...
8.
Novel p-Functionalized Chromen-4-on-3-yl Chalcones Bearing Astonishing Boronic Acid Moiety as MDM2 Inhibitor: Synthesis, Cytotoxic Evaluation and Simulation Studies
Bhatia R, Singh L, Garg R, Kaur M, Yadav M, Madan J, et al.
Med Chem . 2019 Jun; 16(2):212-228. PMID: 31146672
Background: Novel 4-[3-(6/7/8-Substituted 4-Oxo-4H-chromen-3-yl)acryloyl]phenylboronic acid derivatives (5a-h) as well as other 6/7/8-substituted-3-(3-oxo-3-(4-substitutedphenyl) prop-1-enyl)-4H-chromen-4-one derivatives (3a-u) have been designed as p53-MDM2 pathway inhibitors and reported to possess significant cytotoxic properties against...
9.
Characterization of pioglitazone cyclodextrin complexes: Molecular modeling to in vivo evaluation
Bramhane D, Kulkarni P, Martis E, Pissurlenkar R, Coutinho E, Nagarsenker M
J Pharm Bioallied Sci . 2016 May; 8(2):161-9. PMID: 27134470
Aims: The objective of present study was to study the influence of different β-cyclodextrin derivatives and different methods of complexation on aqueous solubility and consequent translation in in vivo performance...
10.
Physical basis for the ofloxacin-induced acceleration of lysozyme aggregation and polymorphism in amyloid fibrils
Muthu S, Mothi N, Shiriskar S, Pissurlenkar R, Kumar A, Ahmad B
Arch Biochem Biophys . 2016 Jan; 592:10-9. PMID: 26777461
Aggregation of globular proteins is an intractable problem which generally originates from partially folded structures. The partially folded structures first collapse non-specifically and then reorganize into amyloid-like fibrils via one...