Kow Essuman
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Explore the profile of Kow Essuman including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
675
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Recent Articles
1.
Klontz E, Obi J, Wang Y, Glendening G, Carr J, Tsibouris C, et al.
J Biol Chem
. 2023 Sep;
299(11):105290.
PMID: 37758001
Toll-like and interleukin-1/18 receptor/resistance (TIR) domain-containing proteins function as important signaling and immune regulatory molecules. TIR domain-containing proteins identified in eukaryotic and prokaryotic species also exhibit NAD+ hydrolase activity in...
2.
Essuman K, Milbrandt J, Dangl J, Nishimura M
Science
. 2022 Jul;
377(6605):eabo0001.
PMID: 35857622
In the 20th century, researchers studying animal and plant signaling pathways discovered a protein domain that is shared across diverse innate immune systems: the Toll/interleukin-1/resistance gene (TIR) domain. The TIR...
3.
Brace E, Essuman K, Mao X, Palucki J, Sasaki Y, Milbrandt J, et al.
PLoS Genet
. 2022 Jun;
18(6):e1010246.
PMID: 35737728
SARM1 is the founding member of the TIR-domain family of NAD+ hydrolases and the central executioner of pathological axon degeneration. SARM1-dependent degeneration requires NAD+ hydrolysis. Prior to the discovery that...
4.
Awad A, Essuman K, Regenhardt R, Leslie-Mazwi T, Patel A, Stapleton C
Neurohospitalist
. 2022 Apr;
12(2):418-419.
PMID: 35419120
No abstract available.
5.
Wan L, Essuman K, Anderson R, Sasaki Y, Monteiro F, Chung E, et al.
Science
. 2019 Aug;
365(6455):799-803.
PMID: 31439793
Plant nucleotide-binding leucine-rich repeat (NLR) immune receptors activate cell death and confer disease resistance by unknown mechanisms. We demonstrate that plant Toll/interleukin-1 receptor (TIR) domains of NLRs are enzymes capable...
6.
Essuman K, Summers D, Sasaki Y, Mao X, Yim A, DiAntonio A, et al.
Curr Biol
. 2018 Feb;
28(3):421-430.e4.
PMID: 29395922
The Toll/interleukin-1 receptor (TIR) domain is the signature signaling domain of Toll-like receptors (TLRs) and their adaptors, serving as a scaffold for the assembly of protein complexes for innate immune...
7.
Essuman K, Summers D, Sasaki Y, Mao X, DiAntonio A, Milbrandt J
Neuron
. 2017 Mar;
93(6):1334-1343.e5.
PMID: 28334607
Axonal degeneration is an early and prominent feature of many neurological disorders. SARM1 is the central executioner of the axonal degeneration pathway that culminates in depletion of axonal NAD, yet...
8.
Schug J, McKenna L, Walton G, Hand N, Mukherjee S, Essuman K, et al.
BMC Genomics
. 2013 Apr;
14:264.
PMID: 23597149
Background: Validation of physiologic miRNA targets has been met with significant challenges. We employed HITS-CLIP to identify which miRNAs participate in liver regeneration, and to identify their target mRNAs. Results:...