Kouyuki Hirayasu
Overview
Explore the profile of Kouyuki Hirayasu including associated specialties, affiliations and a list of published articles.
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28
Citations
684
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Recent Articles
1.
Nagasaki M, Hirayasu K, Khor S, Otokozawa R, Sekiya Y, Kawai Y, et al.
Hum Immunol
. 2025 Mar;
86(3):111272.
PMID: 40054016
Leukocyte immunoglobulin-like receptors (LILRs), encoded on human chromosome 19q13.4, comprise a set of 11 immunoglobulin superfamily receptors known for their genetic heterogeneity. Notably, LILRB3 and LILRA6 within this cluster exhibit...
2.
Li Y, Hirayasu K, Hasegawa G, Tomita Y, Hashikawa Y, Hiwa R, et al.
Front Immunol
. 2024 Oct;
15:1435236.
PMID: 39376567
The leukocyte immunoglobulin-like receptor (LILR) family, a group of primate-specific immunoreceptors, is widely expressed on most immune cells and regulates immune responses through interactions with various ligands. The inhibitory type,...
3.
Zaimoku Y, Sakai K, Tsuji N, Hosomichi K, Yamada S, Tran D, et al.
Br J Haematol
. 2024 Aug;
205(5):1995-1999.
PMID: 39155468
We describe the case of a 74-year-old man with severe aplastic anaemia who experienced persistent remission attributed to proliferation of HLA allele-deficient clones. Despite an initial worsening of pancytopenia with...
4.
Hirayasu K, Khor S, Kawai Y, Shimada M, Omae Y, Hasegawa G, et al.
Front Immunol
. 2024 May;
15:1398935.
PMID: 38807600
Leukocyte immunoglobulin (Ig)-like receptors (LILRs) on human chromosome 19q13.4 encode 11 immunoglobulin superfamily receptors, exhibiting genetic diversity within and between human populations. Among the genes, the genomic region surrounding and...
5.
Su M, Inui M, Wong Y, Takahashi M, Sugahara-Tobinai A, Ono K, et al.
Int Immunol
. 2021 Jun;
33(8):447-458.
PMID: 34089617
The extracellular matrix (ECM) is the basis for virtually all cellular processes and is also related to tumor metastasis. Fibronectin (FN), a major ECM macromolecule expressed by different cell types...
6.
Sakoguchi A, Saito F, Hirayasu K, Shida K, Matsuoka S, Itagaki S, et al.
Biochem Biophys Res Commun
. 2021 Mar;
548:167-173.
PMID: 33647792
Plasmodium falciparum causes the most severe form of malaria. Acquired immunity against P. falciparum provides insufficient protection even after repeated infections. Therefore, P. falciparum parasites might exploit inhibitory receptors for...
7.
Hirayasu K, Sun J, Hasegawa G, Hashikawa Y, Hosomichi K, Tajima A, et al.
J Hum Genet
. 2021 Feb;
66(7):739-748.
PMID: 33526815
Leukocyte immunoglobulin (Ig)-like receptors (LILRs) are encoded by members of a human multigene family, comprising 11 protein-coding genes and two pseudogenes. Among the LILRs, LILRB3 and LILRA6 show the highest...
8.
Yamazaki R, Furukawa A, Hirayasu K, Yumoto K, Fukuhara H, Arase H, et al.
J Biol Chem
. 2020 May;
295(28):9531-9541.
PMID: 32424043
Human leukocyte immunoglobulin-like receptors (LILRs) typically regulate immune activation by binding to the human leukocyte antigen class I molecules. LILRA2, a member of the LILR family, was recently reported to...
9.
Arase N, Wataya-Kaneda M, Murota H, Nakagawa Y, Yamaoka T, Itoi-Ochi S, et al.
J Dermatol
. 2020 Feb;
47(4):426-429.
PMID: 32077120
Pediatric cutaneous mastocytosis (CM) is mainly attributed to gain-of-function mutations in KIT in mast cells. On the other hand, growing evidence suggests that CM patients exist without KIT mutations. To...
10.
Deng M, Gui X, Kim J, Xie L, Chen W, Li Z, et al.
Nature
. 2018 Oct;
562(7728):605-609.
PMID: 30333625
Immune checkpoint blockade therapy has been successful in treating some types of cancer but has not shown clinical benefits for treating leukaemia. This result suggests that leukaemia uses unique mechanisms...