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Korin E Leffler

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Articles 5
Citations 31
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Recent Articles
1.
Parekh R, White A, Leffler K, Biancardi V, Eells J, Abdel-Rahman A, et al.
Sci Rep . 2021 Oct; 11(1):21050. PMID: 34702886
Brain orexin system hyperactivity contributes to neurogenic hypertension. We previously reported upregulated neuronal kinin B1 receptor (B1R) expression in hypertension. However, the role of central B1R activation on the orexin...
2.
Fouda M, Leffler K, Abdel-Rahman A
Life Sci . 2020 Apr; 250:117598. PMID: 32243927
Aims: To investigate if autonomic dysregulation is exacerbated in female rats, subjected to diabetes mellitus (DM), via a paradoxical estrogen (E)-evoked provocation of neuroinflammation/injury of the hypothalamic paraventricular nucleus (PVN)....
3.
Leffler K, Abdel-Rahman A
J Cardiovasc Pharmacol . 2019 Dec; 75(3):259-267. PMID: 31868825
ur preclinical findings replicated women's hypersensitivity to type-2 diabetes mellitus (T2DM)-evoked cardiac dysfunction along with demonstrating estrogen (E2)-dependent disruption of the cardiac adiponectin (APN)-connexin43 (Cx43) signaling. Whether the latter molecular...
4.
Leffler K, Abdel-Rahman A
J Pharmacol Exp Ther . 2018 Dec; 368(2):208-217. PMID: 30523063
The reasons for the higher severity of type 2 diabetes (T2DM)-associated cardiomyopathy in women, despite their inherent estrogen (E)-dependent cardioprotection, remain unknown. We hypothesized that the reliance of the healthy...
5.
Abbott B, Buckalew A, Leffler K
Birth Defects Res A Clin Mol Teratol . 2005 May; 73(6):447-54. PMID: 15880701
Background: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is teratogenic in mice, producing cleft palate (CP). TCDD exposure disrupts expression of epidermal growth factor (EGF) receptor, EGF, and transforming growth factor-alpha (TGFalpha) in the palate...