Konstantin B Zeldovich
Overview
Explore the profile of Konstantin B Zeldovich including associated specialties, affiliations and a list of published articles.
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29
Citations
1075
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Recent Articles
11.
Prachanronarong K, Ozen A, Thayer K, Yilmaz L, Zeldovich K, Bolon D, et al.
J Chem Theory Comput
. 2016 Dec;
12(12):6098-6108.
PMID: 27951676
Neuraminidase (NA) inhibitors are used for the prevention and treatment of influenza A virus infections. Two subtypes of NA, N1 and N2, predominate in viruses that infect humans, but differential...
12.
Bank C, Renzette N, Liu P, Matuszewski S, Shim H, Foll M, et al.
Evolution
. 2016 Aug;
70(11):2470-2484.
PMID: 27566611
The rapid evolution of drug resistance remains a critical public health concern. The treatment of influenza A virus (IAV) has proven particularly challenging, due to the ability of the virus...
13.
Jiang L, Liu P, Bank C, Renzette N, Prachanronarong K, Yilmaz L, et al.
J Mol Biol
. 2015 Dec;
428(3):538-553.
PMID: 26656922
The therapeutic benefits of the neuraminidase (NA) inhibitor oseltamivir are dampened by the emergence of drug resistance mutations in influenza A virus (IAV). To investigate the mechanistic features that underlie...
14.
Venev S, Zeldovich K
J Chem Phys
. 2015 Aug;
143(5):055101.
PMID: 26254668
Evolution of proteins in bacteria and archaea living in different conditions leads to significant correlations between amino acid usage and environmental temperature. The origins of these correlations are poorly understood,...
15.
Zeldovich K, Liu P, Renzette N, Foll M, Pham S, Venev S, et al.
Mol Biol Evol
. 2015 Feb;
32(6):1519-32.
PMID: 25713211
Influenza A virus (IAV) has a segmented genome that allows for the exchange of genome segments between different strains. This reassortment accelerates evolution by breaking linkage, helping IAV cross species...
16.
Foll M, Poh Y, Renzette N, Ferrer-Admetlla A, Bank C, Shim H, et al.
PLoS Genet
. 2014 Mar;
10(2):e1004185.
PMID: 24586206
The challenge of distinguishing genetic drift from selection remains a central focus of population genetics. Time-sampled data may provide a powerful tool for distinguishing these processes, and we here propose...
17.
Renzette N, Caffrey D, Zeldovich K, Liu P, Gallagher G, Aiello D, et al.
J Virol
. 2013 Oct;
88(1):272-81.
PMID: 24155392
Influenza A virus (IAV) is a major cause of morbidity and mortality throughout the world. Current antiviral therapies include oseltamivir, a neuraminidase inhibitor that prevents the release of nascent viral...
18.
Jiang L, Mishra P, Hietpas R, Zeldovich K, Bolon D
PLoS Genet
. 2013 Jul;
9(6):e1003600.
PMID: 23825969
In natural systems, selection acts on both protein sequence and expression level, but it is unclear how selection integrates over these two dimensions. We recently developed the EMPIRIC approach to...
19.
Venev S, Zeldovich K
Phys Rev Lett
. 2013 Mar;
110(9):098104.
PMID: 23496749
The genome of influenza A virus consists of eight separate RNA segments, which are selectively packaged into virions prior to virus budding. The microscopic mechanism of highly selective packaging involves...
20.
Roscoe B, Thayer K, Zeldovich K, Fushman D, Bolon D
J Mol Biol
. 2013 Feb;
425(8):1363-77.
PMID: 23376099
The amino acid sequence of a protein governs its function. We used bulk competition and focused deep sequencing to investigate the effects of all ubiquitin point mutants on yeast growth...