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Kong Wai Tan

Explore the profile of Kong Wai Tan including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 44
Citations 88
Followers 0
Related Specialties
Molecular Biology
Biochemistry
Chemistry
Top 10 Co-Authors
Seik Weng Ng
Mohd Jamil Maah
Chew Hee Ng
Salman A Khan
Abdullah M Asiri
Kae Shin Sim
M Jamil Maah
Nur Syamimi Ahmad Tajidi
Zainudin Arifin
Edward R T Tiekink
Published In
Acta Crystallogr Sect E Struct Rep Online
Spectrochim Acta A Mol Biomol Spectrosc
J Inorg Biochem
Eur J Med Chem
Malar J
Affiliations
Soon will be listed here.
Recent Articles
1.
Sialic acid detection and theranostic activity of phenylboronic acid-based fluorescent probe in human colorectal adenocarcinoma HT-29 cells
Ng M, Chan W, Tan M, Tan C, Tiong S, Sim K, et al.
Spectrochim Acta A Mol Biomol Spectrosc . 2024 Sep; 325:125116. PMID: 39276466
A new probe, 4-(((3',6'-bis(diethylamino)-3-oxospiro[isoindoline-1,9'-xanthen]-2-yl)imino)methyl)phenyl)boronic acid (R4B) was prepared by facile condensation of 4-formylphenylboronic acid and rhodamine B hydrazide. R4B was characterized by spectroscopic methods and single crystal X-ray diffraction. The...
2.
Dinuclear and mononuclear metal(II) polypyridyl complexes against drug-sensitive and drug-resistant Plasmodium falciparum and their mode of action
Lai J, Maah M, Tan K, Sarip R, Lim Y, Ganguly R, et al.
Malar J . 2022 Dec; 21(1):386. PMID: 36528584
Background: Malaria remains one of the most virulent and deadliest parasitic disease in the world, particularly in Africa and Southeast Asia. Widespread occurrence of artemisinin-resistant Plasmodium falciparum strains from the...
3.
Synthesis, Structural Characterization, Hirshfeld Surface Analysis, and Antibacterial Study of Pd(II) and Ni(II) Schiff Base Complexes Derived from Aliphatic Diamine
Nasaruddin N, Ahmad S, Sirat S, Tan K, Zakaria N, Mohamad Nazam S, et al.
ACS Omega . 2022 Dec; 7(47):42809-42818. PMID: 36467908
A Schiff base bearing two methyl substituents, namely, 6,6'-((1,1')-((2,2-dimethylpropane-1,3-diyl) bis(azanylylidene)) bis(methanylylidene)) bis(2-methylphenol) [HAD1Me] was synthesized and characterized through physicochemical and spectroscopic analyses. Then, the Schiff base was complexed with Pd(II)...
4.
A rhodamine based chemosensor for solvent dependent chromogenic sensing of cobalt (II) and copper (II) ions with good selectivity and sensitivity: Synthesis, filter paper test strip, DFT calculations and cytotoxicity
Chan W, Saad H, Sim K, Lee V, Ang C, Yeong K, et al.
Spectrochim Acta A Mol Biomol Spectrosc . 2021 Jul; 262:120099. PMID: 34198119
A new chemosensor 1 was synthesized by reacting rhodamine B hydrazide and 2,3,4-trihydroxybenzaldehyde, which was then characterized by spectroscopic techniques and single crystal X-ray crystallography. Sensor 1 has the ability...
5.
Nickel and zinc complexes of testosterone N4-substituted thiosemicarbazone: Selective cytotoxicity towards human colorectal carcinoma cell line HCT 116 and their cell death mechanisms
Heng M, Sim K, Tan K
J Inorg Biochem . 2020 May; 208:111097. PMID: 32438269
Two new Schiff base ligands (TE and TF) were prepared from conjugation of testosterone with 4-(4-ethylphenyl)-3-thiosemicarbazide and 4-(4-fluorophenyl)-3-thiosemicarbazide, respectively. Their nickel (NE and NF) and zinc (ZE and ZF) complexes...
6.
Thiosemicarbazone Derivative Induces in vitro Apoptosis in Metastatic PC-3 Cells via Activation of Mitochondrial Pathway
Sinniah S, Tan K, Ng S, Sim K
Anticancer Agents Med Chem . 2016 Sep; 17(5):741-753. PMID: 27671302
Background: Thiosemicarbazone (TSC) is a Schiff base that has been receiving considerable attention owing to its promising biological implication and remarkable pharmacological properties. The most promising drug candidate of this...
7.
Topoisomerase I inhibition and DNA cleavage by zinc, copper, and nickel derivatives of 2-[2-bromoethyliminomethyl]-4-[ethoxymethyl]phenol complexes exhibiting anti-proliferation and anti-metastasis activity
Lee S, Tan K, Ng S
J Inorg Biochem . 2016 Feb; 159:14-21. PMID: 26901628
Three transition metal derivatives (Zn, Cu, and Ni) of 2-[2-bromoethyliminomethyl]-4-[ethoxymethyl]phenol (L) were synthesized by the reaction of the metal salts with the Schiff base ligand in one pot. In the...
8.
Synthesis of a DNA-targeting nickel (II) complex with testosterone thiosemicarbazone which exhibits selective cytotoxicity towards human prostate cancer cells (LNCaP)
Heng M, Sinniah S, Teoh W, Sim K, Ng S, Cheah Y, et al.
Spectrochim Acta A Mol Biomol Spectrosc . 2015 Jun; 150:360-72. PMID: 26057090
Testosterone thiosemicarbazone, L and its nickel (II) complex 1 were synthesized and characterized by using FTIR, CHN, (1)H NMR, and X-ray crystallography. X-ray diffraction study confirmed the formation of L...
9.
Copper complexes with phosphonium containing hydrazone ligand: topoisomerase inhibition and cytotoxicity study
Chew S, Lo K, Lee S, Heng M, Teoh W, Sim K, et al.
Eur J Med Chem . 2014 Mar; 76:397-407. PMID: 24602785
Four new copper(II) complexes containing phosphonium substituted hydrazone (L) with the formulations [CuL]Cl(3), [Cu(phen)L]Cl(4), [Cu(bpy)L]Cl(5), [Cu(dbpy)L]Cl(6), (where L = doubly deprotonated hydrazone; phen = 1,10'-phenanthroline; bpy = 2,2'-bipyridine; dbpy =...
10.
Zinc (II) complex with a cationic Schiff base ligand: synthesis, characterization, and biological studies
Lee S, Tan K, Ng S, Ooi K, Ang K, Abdah M
Spectrochim Acta A Mol Biomol Spectrosc . 2013 Nov; 121:101-8. PMID: 24231745
A cationic Schiff base ligand, TSB (L) and its Zn (II) complex (1) were synthesized and characterized by using CHN, (1)H-NMR, FT-IR, UV, LC-MS, and X-ray methods. Their ability to...