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Kohji Hizume

Explore the profile of Kohji Hizume including associated specialties, affiliations and a list of published articles. Areas
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Articles 23
Citations 438
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Recent Articles
1.
Hizume K
Biosci Biotechnol Biochem . 2024 Aug; 88(11):1270-1278. PMID: 39103894
During DNA replication, core histones that form nucleosomes on template strands are evicted and associate with newly synthesized strands to reform nucleosomes. Mcm2, a subunit of the Mcm2-7 complex, which...
2.
Hizume K, Araki H
FEBS Lett . 2019 Jun; 593(13):1449-1458. PMID: 31199500
When a cell divides prior to completion of DNA replication, serious DNA damage may occur. Thus, in addition to accuracy, the processivity of the replication forks is important. DNA synthesis...
3.
Hizume K, Endo S, Muramatsu S, Kobayashi T, Araki H
Genes Dev . 2018 Sep; 32(19-20):1315-1320. PMID: 30232092
The proper pausing of replication forks at barriers on chromosomes is important for genome integrity. However, the detailed mechanism underlying this process has not been well elucidated. Here, we successfully...
4.
Hizume K, Kominami H, Kobayashi K, Yamada H, Araki H
Biochemistry . 2017 May; 56(19):2435-2445. PMID: 28459551
The formation of the pre-replicative complex (pre-RC) during the G1 phase, which is also called the licensing of DNA replication, is the initial and essential step of faithful DNA replication...
5.
Hizume K, Yagura M, Araki H
Genes Cells . 2013 Jun; 18(9):764-79. PMID: 23795651
Chromosomal replication origins, where DNA replication is initiated, are determined in eukaryotic cells by specific binding of a six-subunit origin recognition complex (ORC). Many biochemical analyses have showed the detailed...
6.
Prieto E, Hizume K, Kobori T, Yoshimura S, Takeyasu K
Biosci Biotechnol Biochem . 2012 Dec; 76(12):2261-6. PMID: 23221705
Histones are highly conserved proteins among eukaryotes. However, yeast histones are more divergent in their sequences. In particular, the histone tail regions of the fission yeast, Schizosaccharomyces pombe, have fewer...
7.
Hirano Y, Hizume K, Kimura H, Takeyasu K, Haraguchi T, Hiraoka Y
J Biol Chem . 2012 Oct; 287(51):42654-63. PMID: 23100253
Inner nuclear membrane proteins provide a structural framework for chromatin, modulating transcription beneath the nuclear envelope. Lamin B receptor (LBR) is a classical inner nuclear membrane protein that associates with...
8.
Hizume K, Araki S, Hata K, Prieto E, Kundu T, Yoshikawa K, et al.
Arch Histol Cytol . 2012 May; 73(3):149-63. PMID: 22572182
The acetylation of histone tails is a key factor in the maintenance of chromatin dynamics and cellular homeostasis. The hallmark of active chromatin is the hyper-acetylation of histones, which appears...
9.
Takahashi H, Hizume K, Kumeta M, Yoshimura S, Takeyasu K
Arch Histol Cytol . 2011 Apr; 72(4-5):217-25. PMID: 21471656
Atomic force microscopy (AFM) has been a useful technique to visualize cellular and molecular structures at single-molecule resolution. The combination of imaging and force modes has also allowed the characterization...
10.
Suzuki Y, Higuchi Y, Hizume K, Yokokawa M, Yoshimura S, Yoshikawa K, et al.
Ultramicroscopy . 2010 Mar; 110(6):682-8. PMID: 20236766
Nucleosome is a fundamental structural unit of chromatin, and the exposure from or occlusion into chromatin of genomic DNA is closely related to the regulation of gene expression. In this...