Koen Schepers
Overview
Explore the profile of Koen Schepers including associated specialties, affiliations and a list of published articles.
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Articles
30
Citations
1642
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0
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Recent Articles
1.
van Halteren A, Suwandi J, Tuit S, Borst J, Laban S, Tsonaka R, et al.
Blood
. 2022 Aug;
141(11):1277-1292.
PMID: 36044666
Acute graft-versus-host disease (aGVHD) is an immune cell‒driven, potentially lethal complication of allogeneic hematopoietic stem cell transplantation affecting diverse organs, including the skin, liver, and gastrointestinal (GI) tract. We applied...
2.
Barnhoorn M, van der Meulen-de Jong A, Schrama E, Plug L, Verspaget H, Fibbe W, et al.
Stem Cells Transl Med
. 2022 Aug;
11(9):932-945.
PMID: 35984079
Locally applied mesenchymal stromal cells (MSCs) have the capacity to promote the healing of perianal fistulas in Crohn's disease (CD) and are under clinical development for the treatment of proctitis...
3.
Rodriguez Ruiz A, Dicks A, Tuerlings M, Schepers K, van Pel M, Nelissen R, et al.
Cell Tissue Res
. 2021 Jul;
386(2):309-320.
PMID: 34241697
Cartilage has little intrinsic capacity for repair, so transplantation of exogenous cartilage cells is considered a realistic option for cartilage regeneration. We explored whether human-induced pluripotent stem cells (hiPSCs) could...
4.
Das R, Roosloot R, van Pel M, Schepers K, Driessen M, Fibbe W, et al.
J Transl Med
. 2019 Jul;
17(1):241.
PMID: 31340829
Background: Cell-based therapies have the potential to become treatment options for many diseases, but efficient scale-out of these therapies has proven to be a major hurdle. Bioreactors can be used...
5.
Pennings I, van Dijk L, van Huuksloot J, Fledderus J, Schepers K, Braat A, et al.
J Tissue Eng Regen Med
. 2019 Jan;
13(3):433-445.
PMID: 30650247
To introduce a functional vascular network into tissue-engineered bone equivalents, human endothelial colony forming cells (ECFCs) and multipotent mesenchymal stromal cells (MSCs) can be cocultured. Here, we studied the impact...
6.
Broekman W, Khedoe P, Schepers K, Roelofs H, Stolk J, Hiemstra P
Thorax
. 2018 Apr;
73(6):565-574.
PMID: 29653970
COPD is characterised by tissue destruction and inflammation. Given the lack of curative treatments and the progressive nature of the disease, new treatments for COPD are highly relevant. In vitro...
7.
Devignes C, Aslan Y, Brenot A, Devillers A, Schepers K, Fabre S, et al.
Proc Natl Acad Sci U S A
. 2018 Jan;
115(5):E992-E1001.
PMID: 29339479
Bone metastasis involves dynamic interplay between tumor cells and the local stromal environment. In bones, local hypoxia and activation of the hypoxia-inducible factor (HIF)-1α in osteoblasts are essential to maintain...
8.
Gomez-Puerto M, Folkerts H, Wierenga A, Schepers K, Schuringa J, Coffer P, et al.
Stem Cells
. 2016 Mar;
34(6):1651-63.
PMID: 26930546
Autophagy is a highly regulated catabolic process that involves sequestration and lysosomal degradation of cytosolic components such as damaged organelles and misfolded proteins. While autophagy can be considered to be...
9.
van Pel M, Fibbe W, Schepers K
Ann N Y Acad Sci
. 2015 Dec;
1370(1):55-64.
PMID: 26713726
Hematopoietic stem cells (HSCs) reside in specific niches that provide various instructive cues that regulate HSC self-renewal and their development into all mature cells of the peripheral blood. Progress in...
10.
Schepers K, Fibbe W
Ann N Y Acad Sci
. 2015 Dec;
1370(1):15-23.
PMID: 26713608
Mesenchymal stromal cells (MSCs) are increasingly used in the treatment of a variety of clinical conditions and to modulate immune responses in conditions related to auto-/alloimmunity, including graft-versus-host disease (GvHD)....