Klaus H Hansen
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Explore the profile of Klaus H Hansen including associated specialties, affiliations and a list of published articles.
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10
Citations
2454
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Recent Articles
1.
Bracken A, Kleine-Kohlbrecher D, Dietrich N, Pasini D, Gargiulo G, Beekman C, et al.
Genes Dev
. 2023 Oct;
37(17-18):861.
PMID: 37852794
No abstract available.
2.
Flores-Morales A, Bergmann T, Lavallee C, Batth T, Lin D, Lerdrup M, et al.
Clin Cancer Res
. 2018 Oct;
25(2):595-608.
PMID: 30274982
Purpose: An increasing number of castration-resistant prostate cancer (CRPC) tumors exhibit neuroendocrine (NE) features. NE prostate cancer (NEPC) has poor prognosis, and its development is poorly understood. We applied mass...
3.
Hansen K, Helin K
Epigenetics
. 2009 Apr;
4(3):133-8.
PMID: 19377285
Maintenance of gene expression through epigenetic mechanisms such as DNA- and histone-methylation is essential for preserving cellular identity and function. Multiplication of eukaryotic cells requires that the DNA content of...
4.
Hansen K, Bracken A, Pasini D, Dietrich N, Gehani S, Monrad A, et al.
Nat Cell Biol
. 2008 Oct;
10(11):1291-300.
PMID: 18931660
Organization of chromatin by epigenetic mechanisms is essential for establishing and maintaining cellular identity in developing and adult organisms. A key question that remains unresolved about this process is how...
5.
Pasini D, Hansen K, Christensen J, Agger K, Cloos P, Helin K
Genes Dev
. 2008 May;
22(10):1345-55.
PMID: 18483221
Polycomb group (PcG) proteins regulate important cellular processes such as embryogenesis, cell proliferation, and stem cell self-renewal through the transcriptional repression of genes determining cell fate decisions. The Polycomb-Repressive Complex...
6.
Bracken A, Kleine-Kohlbrecher D, Dietrich N, Pasini D, Gargiulo G, Beekman C, et al.
Genes Dev
. 2007 Mar;
21(5):525-30.
PMID: 17344414
The p16INK4A and p14ARF proteins, encoded by the INK4A-ARF locus, are key regulators of cellular senescence, yet the mechanisms triggering their up-regulation are not well understood. Here, we show that...
7.
Dietrich N, Bracken A, Trinh E, Schjerling C, Koseki H, Rappsilber J, et al.
EMBO J
. 2007 Mar;
26(6):1637-48.
PMID: 17332741
The Polycomb group (PcG) proteins are essential for embryogenesis, and their expression is often found deregulated in human cancer. The PcGs form two major protein complexes, called polycomb repressive complexes...
8.
Christensen J, Agger K, Cloos P, Pasini D, Rose S, Sennels L, et al.
Cell
. 2007 Feb;
128(6):1063-76.
PMID: 17320161
Methylation of histones has been regarded as a stable modification defining the epigenetic program of the cell, which regulates chromatin structure and transcription. However, the recent discovery of histone demethylases...
9.
Cloos P, Christensen J, Agger K, Maiolica A, Rappsilber J, Antal T, et al.
Nature
. 2006 May;
442(7100):307-11.
PMID: 16732293
Methylation of lysine and arginine residues on histone tails affects chromatin structure and gene transcription. Tri- and dimethylation of lysine 9 on histone H3 (H3K9me3/me2) is required for the binding...
10.
Bracken A, Dietrich N, Pasini D, Hansen K, Helin K
Genes Dev
. 2006 Apr;
20(9):1123-36.
PMID: 16618801
The Polycomb group (PcG) proteins form chromatin-modifying complexes that are essential for embryonic development and stem cell renewal and are commonly deregulated in cancer. Here, we identify their target genes...