Klaas de Lint
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Explore the profile of Klaas de Lint including associated specialties, affiliations and a list of published articles.
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10
Citations
104
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Recent Articles
1.
van den Heuvel D, Rodriguez-Martinez M, van der Meer P, Nieto Moreno N, Park J, Kim H, et al.
Cell
. 2024 Nov;
187(25):7107-7125.e25.
PMID: 39547229
Transcription-coupled DNA repair (TCR) removes bulky DNA lesions impeding RNA polymerase II (RNAPII) transcription. Recent studies have outlined the stepwise assembly of TCR factors CSB, CSA, UVSSA, and transcription factor...
2.
van den Heuvel D, Rodriguez-Martinez M, van der Meer P, Nieto Moreno N, Park J, Kim H, et al.
bioRxiv
. 2024 Aug;
PMID: 39091731
Transcription-coupled DNA repair (TCR) removes bulky DNA lesions impeding RNA polymerase II (RNAPII) transcription. Recent studies have outlined the stepwise assembly of TCR factors CSB, CSA, UVSSA, and TFIIH around...
3.
van Schie J, de Lint K, Molenaar T, Moronta Gines M, Balk J, Rooimans M, et al.
Nucleic Acids Res
. 2023 Sep;
51(18):9594-9609.
PMID: 37702151
The cohesin complex regulates higher order chromosome architecture through maintaining sister chromatid cohesion and folding chromatin by DNA loop extrusion. Impaired cohesin function underlies a heterogeneous group of genetic syndromes...
4.
van Schie J, de Lint K, Pai G, Rooimans M, Wolthuis R, de Lange J
Life Sci Alliance
. 2023 Jan;
6(2).
PMID: 36622344
The leading strand-oriented alternative PCNA clamp loader DSCC1-RFC functions in DNA replication, repair, and sister chromatid cohesion (SCC), but how it facilitates these processes is incompletely understood. Here, we confirm...
5.
Roohollahi K, de Jong Y, Pai G, Zaini M, de Lint K, Sie D, et al.
Sci Rep
. 2022 Apr;
12(1):5768.
PMID: 35388046
No abstract available.
6.
Roohollahi K, de Jong Y, Pai G, Zaini M, de Lint K, Sie D, et al.
Sci Rep
. 2022 Jan;
12(1):45.
PMID: 34997070
Head-and-neck squamous cell carcinomas (HNSCCs) are relatively common in patients with Fanconi anemia (FA), a hereditary chromosomal instability disorder. Standard chemo-radiation therapy is not tolerated in FA due to an...
7.
van der Weegen Y, de Lint K, van den Heuvel D, Nakazawa Y, Mevissen T, van Schie J, et al.
Nat Cell Biol
. 2021 Jun;
23(6):595-607.
PMID: 34108663
Cells employ transcription-coupled repair (TCR) to eliminate transcription-blocking DNA lesions. DNA damage-induced binding of the TCR-specific repair factor CSB to RNA polymerase II (RNAPII) triggers RNAPII ubiquitylation of a single...
8.
Heinio C, Havunen R, Santos J, de Lint K, Cervera-Carrascon V, Kanerva A, et al.
Cells
. 2020 Apr;
9(4).
PMID: 32225009
In order to break tumor resistance towards traditional treatments, we investigate the response of tumor and immune cells to a novel, cytokine-armed oncolytic adenovirus: Ad5/3-d24-E2F-hTNFa-IRES-hIL2 (also known as TILT-123 and...
9.
Jastrzebski K, Thijssen B, Kluin R, de Lint K, Majewski I, Beijersbergen R, et al.
Cancer Res
. 2018 May;
78(15):4396-4410.
PMID: 29844118
Cancer cell lines differ greatly in their sensitivity to anticancer drugs as a result of different oncogenic drivers and drug resistance mechanisms operating in each cell line. Although many of...
10.
de Lint K, Poell J, Soueidan H, Jastrzebski K, Vidal Rodriguez J, Lieftink C, et al.
Mol Cancer Ther
. 2016 May;
15(7):1545-56.
PMID: 27196766
Targeted therapies have proven invaluable in the treatment of breast cancer, as exemplified by tamoxifen treatment for hormone receptor-positive tumors and trastuzumab treatment for HER2-positive tumors. In contrast, a subset...