Kiyofumi Ninomiya
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Explore the profile of Kiyofumi Ninomiya including associated specialties, affiliations and a list of published articles.
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92
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903
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Recent Articles
1.
Saeki T, Yamamoto S, Akaki J, Tanaka T, Nakasone M, Ikeda H, et al.
J Nat Med
. 2024 Apr;
78(3):576-589.
PMID: 38662301
This study aimed to compare fat accumulation in young and aged mice raised on a high-fat diet and to characterize the obesity-reducing effects of a Kampo medicine, bofutsushosan (BTS; fangfengtongshengsan...
2.
Morikawa T, Inoue N, Yamamoto S, Shiotani M, Manse Y, Ninomiya K
J Nat Med
. 2024 Apr;
78(3):709-721.
PMID: 38575838
Methanol extract of the Cnidium officinale Makino rhizome, which is used as a crude drug Cnidium Rhizome (Cnidii Rhizoma; "Senkyu" in Japanese) and is listed in the Japanese Pharmacopoeia XVIII,...
3.
Sakamoto Y, Inoue N, Nakanishi Y, Ninomiya K, Yoshikawa M, Muraoka O, et al.
Biol Pharm Bull
. 2023 May;
46(6):848-855.
PMID: 37258151
A methanol extract of rhizomes of Picrorhiza kurroa Royle ex Benth. (Plantaginaceae) showed hepatoprotective effects against D-galactosamine (D-GalN)/lipopolysaccharide (LPS)-induced liver injury in mice. We had previously isolated 46 compounds, including...
4.
Nagatomo A, Ninomiya K, Marumoto S, Sakai C, Watanabe S, Ishikawa W, et al.
Int J Mol Sci
. 2022 Nov;
23(21).
PMID: 36361930
The seed oil of Aublet (Andiroba) has been used in folk medicine for its insect-repelling, anti-inflammatory, and anti-malarial activities. This study aimed to examine the triglyceride (TG) reducing effects of...
5.
Ishikawa F, Hirano A, Yoshimori Y, Nishida K, Nakamura S, Takashima K, et al.
RSC Adv
. 2022 Apr;
11(6):3221-3225.
PMID: 35424309
We show that salacinol-type α-glucosidase inhibitors are ligand-compatible with the GH 31 family. Salacinol and its 3'--benzylated analogs inhibit human lysosomal α-glucosidase at submicromolar levels. Simple structure-activity relationship studies reveal...
6.
Nagatomo A, Inoue N, Konno T, Xu Y, Sakamoto C, Sone M, et al.
J Nat Med
. 2022 Mar;
76(3):654-669.
PMID: 35292883
The methanol extract from the leaves of Ilex paraguariensis A. St.-Hil. (Aquifoliaceae), popularly known as mate, maté, or yerba maté, inhibits the intracellular triglyceride accumulation in HepG2 cells and suppresses...
7.
Morikawa T, Manse Y, Luo F, Fukui H, Inoue Y, Kaieda T, et al.
Chem Pharm Bull (Tokyo)
. 2021 May;
69(5):464-471.
PMID: 33952856
A methanol extract from the underground part of Calanthe discolor Lindl. (Orchidaceae) demonstrated significant proliferative activity on human hair follicle dermal papilla cells (HFDPC, % of control: 120.8 ± 0.2%)...
8.
Morikawa T, Ninomiya K, Tanabe G, Matsuda H, Yoshikawa M, Muraoka O
J Nat Med
. 2021 Apr;
75(3):449-466.
PMID: 33900535
During our studies characterizing functional substances from food resources for the prevention and treatment of lifestyle-related diseases, we isolated the active constituents, salacinol (1) and neokotalanol (4), and related thiosugar...
9.
Kobayashi M, Akaki J, Ninomiya K, Yoshikawa M, Muraoka O, Morikawa T, et al.
J Med Food
. 2020 Dec;
24(1):10-17.
PMID: 33370165
The number of diabetes mellitus and borderline diabetes cases is increasing and poses a serious problem worldwide. Plants of the genus are known to have α-glucosidase inhibitory activity and to...
10.
Takashima K, Sakano M, Kinouchi E, Nakamura S, Marumoto S, Ishikawa F, et al.
Bioorg Med Chem Lett
. 2020 Dec;
33:127751.
PMID: 33347966
Four chain-extended analogs (12a-12d) and two related de-O-sulfonated analogs (13a and 13c) by introducing alkyl groups (a: R = CH, b R = CH, c: R = CH, d: R ...