Kirsi H Pietilainen
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Explore the profile of Kirsi H Pietilainen including associated specialties, affiliations and a list of published articles.
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9543
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Recent Articles
11.
Sukhatme M, Kar A, Arasu U, Lee S, Alvarez M, Garske K, et al.
medRxiv
. 2024 Nov;
PMID: 39606332
Given the fast-increasing prevalence of obesity and its comorbidities, it would be critical to improve our understanding of the cell-type level differences between the two key human adipose tissue depots,...
12.
Chen Z, Das S, Kar A, Lee S, Abuhanna K, Alvarez M, et al.
bioRxiv
. 2024 Nov;
PMID: 39554055
Human subcutaneous adipose tissue (SAT) contains a diverse array of cell-types; however, the epigenomic landscape among the SAT cell-types has remained elusive. Our integrative analysis of single-cell resolution DNA methylation...
13.
Joki A, Ahola A, Suojanen L, Pietilainen K
BMC Health Serv Res
. 2024 Nov;
24(1):1367.
PMID: 39516825
Introduction: Healthcare professionals' perspectives are often overlooked in the evaluation of digital weight loss interventions. Thus, we examined how healthcare professionals perceive patient success in a one-year web-based weight management...
14.
Deal M, Kar A, Lee S, Alvarez M, Rajkumar S, Arasu U, et al.
Am J Hum Genet
. 2024 Nov;
111(11):2542-2560.
PMID: 39515300
Mechanisms of abdominal obesity GWAS variants have remained largely unknown. To elucidate these mechanisms, we leveraged subcutaneous adipose tissue (SAT) single nucleus RNA-sequencing and genomics data. After discovering that heritability...
15.
Lietzen M, Guzzardi M, Ojala R, Hentila J, Heiskanen M, Honkala S, et al.
Nutrients
. 2024 Oct;
16(20).
PMID: 39458548
Background/objectives: Obesity impairs intestinal glucose uptake (GU) (intestinal uptake of circulating glucose from blood) and alters gut microbiome. Exercise improves intestinal insulin-stimulated GU and alters microbiome. Genetics influence the risk...
16.
Wong W, Speakman J, Ainslie P, Anderson L, Arab L, Baddou I, et al.
J Nutr
. 2024 Oct;
154(12):3824-3831.
PMID: 39414027
Background: Doubly labeled water is gold standard for measuring total energy expenditure (TEE). Measurements using the method are sensitive to the isotope dilution space ratio (DSR). Accuracy and precision of...
17.
Lietzen M, Mari A, Ojala R, Hentila J, Koskensalo K, Lautamaki R, et al.
Biomolecules
. 2024 Sep;
14(9).
PMID: 39334836
Obesity and sedentarism are associated with increased liver and pancreatic fat content (LFC and PFC, respectively) as well as impaired organ metabolism. Exercise training is known to decrease organ ectopic...
18.
van der Kolk B, Pirinen E, Nicoll R, Pietilainen K, Heinonen S
Trends Endocrinol Metab
. 2024 Sep;
PMID: 39289110
Obesity is a major global health issue with various metabolic complications. Both bariatric surgery and dieting achieve weight loss and improve whole-body metabolism, but vary in their ability to maintain...
19.
Ahola A, Joki A, Suojanen L, Pietilainen K
Ann Med
. 2024 Sep;
56(1):2396562.
PMID: 39229917
Obesity is an important health concern that poses many public health challenges. Evidence-based treatment modalities, capable of cost-effectively reaching large patient groups are needed. In this paper, we present the...
20.
McGowan B, Bruun J, Capehorn M, Pedersen S, Pietilainen K, Muniraju H, et al.
Lancet Diabetes Endocrinol
. 2024 Aug;
12(9):631-642.
PMID: 39089293
Background: There are currently limited data regarding the effect of semaglutide 2·4 mg in individuals with obesity and prediabetes in clinical trials. We aimed to assess the efficacy and safety...